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Critical Care Reviews Newsletter
Newsletter 512 | October 3rd 2021
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Welcome to the 512th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the VAM-IHCA randomised controlled trial, investigating the combination of vasopressin and methylprednisolone for in-hospital cardiac arrest, which we had the privilege of hosting the results presentation of a few nights ago. The full edited video and audio recordings of the livestream are available on the CCR website.
There are also randomised controlled trials on individualised glucose control in critically-ill patients & high dose coupled plasma filtration and adsorption in septic shock patients. On Saturday, the 2021 iteration of the Surviving Sepsis Campaign guidelines were released. There are also great narrative reviews on artificial liver support systems & hemodynamic instability during acute kidney injury and acute renal replacement therapy. If you only have time to read one narrative review article, try this paper on blood purification in sepsis and systemic inflammation.
In other news, Merck issued a press release this week describing how the antiviral molnupiravir reduced the risk of hospitalization or death by approximately 50% compared to placebo for patients with mild or moderate COVID-19 in an interim analysis of a phase 3 study.
Critical Care Reviews Blog
Finally, this week coming we start the Critical Care Reviews Blog, exploring critical care trials in detail, seeking to answer why trials found the results they did. We start with the REST trial, investigating ultra-low tidal volume ventilation facilitated by extra-corporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure.
Research
Randomised Controlled Trials
- Andersen. Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2021;epublished September 29th
- Weinreich. REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19. N Engl J Med 2021;epublished September 29th
- Bohé. Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial. Intensive Care Med 2021;epublished September 29th
- McGuinness. A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial. Vox Sang 2021;epublished September 28th
- Belenguer-Muncharaz. Noninvasive ventilation versus conventional oxygen therapy after extubation failure in high-risk patients in an intensive care unit: a pragmatic clinical trial. Rev Bras Ter Intensiva 2021 ;epublished September 24th
- NICUSeq Study Group. Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial. JAMA Pediatr 2021;epublished September 27th
- Garbero. High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial. Intensive Care Med 2021;epublished October 3rd
- Ibarra-Estrada. Use of Airway Pressure Release Ventilation in Patients With Acute Respiratory Failure Due to Coronavirus Disease 2019: Results of a Single-Center Randomized Controlled Trial. Crit Care Med 2021;epublished September 29th
- Kristen. Standard versus Accelerated Speaking Valve Placement after Percutaneous Tracheostomy: A Randomized Controlled Feasibility Study. Ann Am Thorac Soc 2021;18(10): 1693–1701
- Barrett. Study of Alteplase for Respiratory failure in SARS-Cov2 COVID-19 (STARS): A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized, Controlled Trial. Chest 2021;epublished September 27th
- Lapergue. Effect of Thrombectomy With Combined Contact Aspiration and Stent Retriever vs Stent Retriever Alone on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion. The ASTER2 Randomized Clinical Trial. JAMA 2021;326(12):1158-1169
- Yu. Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial. Crit Care 2021;25:349
Systematic Reviews & Meta Analyses
- Ponnapa Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(10):e1001-e1014
- Karve. The impact of selection criteria and study design on reported survival outcomes in extracorporeal oxygenation cardiopulmonary resuscitation (ECPR): a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med 2021;29(1):142
- Vahedian-Azimi. Comparison of the clinical features in open and closed format intensive care units: A systematic review and meta-analysis. Anaesth Crit Care Pain Med 2021;epublished September 20th
- Castellini. Resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major trauma and uncontrolled haemorrhagic shock: a systematic review with meta-analysis. World J Emerg Surg 2021;16(1):41
- Wang. Efficacy of volume-based feeding (VBF) protocol on critically ill patients: A meta-analysis and systematic review. Asia Pac J Clin Nutr 2021;30(3):392-400
- Areia. The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis. Crit Care 2021;25:351
- Modra. Sex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis. J Crit Care 2021;65:116-123
- Assouline. Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Crit Care Med 2021;epublished September 27th
Observational Studies
- Barbaro. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. Lancet 2021;epublished September 29th
- Perry. Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Lancet 2021;398(10306):1147-1156
- Lee. Cerebral venous sinus thrombosis after vaccination: the UK experience. Lancet 2021;398(10306):1107-1109
- Rose. Communication and Virtual Visiting for Families of Patients in Intensive Care during the COVID-19 Pandemic: A UK National Survey. Ann Am Thorac Soc 2021;18(10):685–1692
- Hrebinko. Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients. A Secondary Analysis of the PAMPer Trial. JAMA Surg 2021;epublished September 22nd
- Cottereau. Handgrip strength to predict extubation outcome: a prospective multicenter trial. Ann Intensive Care 2021;11:144
- van Kammen. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia. JAMA Neurol 2021;epublished September 28th
- Laurikkala. Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial. Crit Care 2021;25:350
- Camporota. Prone Position in Coronavirus Disease 2019 and Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome: An International Multicenter Observational Comparative Study. Crit Care Med 2021;epublished September 24th
- Shein. Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med. 2021 September 27th
- Zaaqoq. Beneficial Effect of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019.
Crit Care Med 2021;epublished September 27th
Guidelines
- Evans. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 2021;epublished October 2nd
- Prevention of venous thromboembolism and haemostasis monitoring in patients with COVID-19: Updated proposals (April 2021): From the French working group on perioperative haemostasis (GIHP) and the French study group on thrombosis and haemostasis (GFHT), in collaboration with the French society of anaesthesia and intensive care (SFAR). Anaesth Crit Care Pain Med 2021;40(4):100919
- Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines. World J Emerg Surg 2021;16:40
- Schell. Essential Emergency and Critical Care: a consensus among global clinical experts. BMJ Global Health 2021;6:e006585
- Swiss Academy of Medical Sciences. Intensive care triage under exceptional resource scarcity. Swiss Med Wkly 2021;151:w30077
Reviews
Clinical
COVID-19
- Kapp. Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology. ASAIO Journal 2021;67(10):1087-1096
- Aziz. An Extracorporeal Membrane Oxygenation First Strategy in COVID-19 Acute Respiratory Distress Syndrome. ASAIO Journal 2021;67(10):1097-1099
- Alayash. The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective. Front Physiol 2021;12:711976
- Khalid. Cardiac manifestations of the coronavirus disease-19: a review of pathogenesis, clinical manifestations, diagnosis, and treatment. Pan Afr Med J 2021;39:173
Neurological
- Kim. Focused Management of Patients With Severe Acute Brain Injury and ARDS. Chest 2021;epublished September 7th
- Lu. Imaging Acute Stroke: From One-Size-Fit-All to Biomarkers. Front Neurol 2021;12:697779
Circulatory
- Kaddoura. Current evidence in the diagnosis and management of cardiogenic shock complicating acute coronary syndrome. Rev Cardiovasc Med 2021;22(3):691-715
- Redant. Rationale of Blood Purification in the Post-Resuscitation Syndrome following Out-of-Hospital Cardiac Arrest: A Narrative Review. Blood Purif 2021;50:750–757
Respiratory
- Depta. Programmed Multi-Level Ventilation: A Strategy for Ventilating Non-Homogenous Lungs. Med Devices 2021;14:277-285
- Sussman. VAPIng into ARDS: Acute respiratory distress syndrome and cardiopulmonary failure. Pharmacol Ther 2021;epublished September 25th
- Gierhardt. Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome. Eur Respir Rev 2021 30:210059
- Raghu. Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease. Eur Respir Rev 2021 30:210094
Hepatobiliary
Renal
Sepsis
Trauma
Paediatrics
- Bline. Immune Function in Critically Ill Septic Children. Pathogens 2021;10(10):1239
- Tesoro. Anesthesiological approach to the floppy child. Minerva Anestesiologica 2021;87(8):940-9
Miscellaneous
Non-Clinical
Editorials
Commentaries
- Busana. The knowns and unknowns of perfusion disturbances in COVID-19 pneumonia. Crit Care 2021;25:352
- McFadyen. The known knowns and known unknowns of vaccine-induced thrombotic thrombocytopaenia. Cardiovascular Research 2021;117(11):e147–e150
- Meurer. Interim Analyses During Group Sequential Clinical Trials. JAMA 2021;epublished October 1st
- El-Baba. Is Aspergillus isolated from respiratory cultures clinically significant? Cleve Clin J Med 2021;88(10):543-546
- Mossad. Fungus among us: A poster child for diagnostic stewardship. Cleve Clin J Med 2021;88(10):541-542
- Woodcock. Integrating Research into Community Practice — Toward Increased Diversity in Clinical Trials. N Engl J Med 2021;epublished October 2nd
Correspondence
- Various. SARS-CoV-2 Human Challenge Studies. Reply. N Engl J Med 2021;epublished September 29th
- Nguyen. Using the lung ultrasound score to monitor disease progression for COVID-19-associated ARDS. Intensive Care Med 2021;epublished September 30th
- Jamale. The AKIKI 2 trial: a case for strategy of initiation instead of timing. Lancet 2021;398(10307):1215
- Ohbe. Immortal time bias in an observational study on enteral nutrition. Resuscitation 2021;166:144-145
- Verma. Myocarditis after Covid-19 mRNA Vaccination. N Engl J Med 2021; 385:1332-1334
- Keehner. Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce. N Engl J Med 2021; 385:1330-1332