Trauma

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Major Trials

Trauma

Sections

Blood Products | Drug Therapy | Devices | Imaging

Blood Product & Fluid Transfusion

Red Cells, Platelets & Plasma

Holcomb. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma: The PROPPR Randomized Clinical Trial. JAMA 2015;313(5):471

Red Cells & Plasma

Hayakawa. The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma. J Intensive Care 2023;11:34
Crombie. Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Haematology 2022;epublished March 7th

Plasma

Prothrombin Complex Concentrate

Bouzat. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive TransfusionThe PROCOAG Randomized Clinical Trial. JAMA 2023;epublished March 21st

Cryoprecipitate

Davenport. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury. The CRYOSTAT-2 Randomized Clinical Trial. JAMA 2023;epublished October 12th

Saline

Bickell. Immediate versus delayed fluid resuscitaion for hypotensive patients with penetrating torso injuries. N Engl J Med 1994;331:1105-1109

Drug Therapy

Antifibrinolytics

Corticosteroids

Roquilly. Hydrocortisone therapy for patients with multiple trauma. The randomized controlled HYPOLYTE study. JAMA 2011;305(12):1201-1209

Oxygenation

Oxygenation

Arleth. Early Restrictive vs Liberal Oxygen for Trauma Patients. The TRAUMOX2 Randomized Clinical Trial. JAMA 2024;epublished December 10th

Devices

REBOA

Jansen. Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage. The UK-REBOA Randomized Clinical Trial. JAMA 2023;epublished October 12th

Imaging

Pan Scan

Sierink. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet 2016;epublished June 28th