CCR26

The Best Critical Care Trials in the World

June 10th - 12th, 2026

Titanic Belfast, Belfast, Northern Ireland

Join us for the LOGICAL trial results, the first of the MEGA-ROX nested RCTs. Will lower oxygenation targets result in better outcomes after cardiac arrest?

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR22 | FIRST-ABC Trial

Drs Padmanabhan Ramnarayan and Paul Mouncey (both London) present the results of the FIRST-ABC trial, comparing high-flow nasal cannulae therapy with CPAP in acute ill children with respiratory failure, at the Critical Care Reviews Meeting 2022. Dr Srinivas Murthy (Vancouver) delivers an editorial, which is followed by a panel discussion including Profs Kathryn Maitland (Kalifi), John Marshall (Toronto) and Marion Campbell (Aberdeen). The session is chaired by Prof Howard Bauchner.

added April 20th

FIRST-ABC (Step Down) Trial Presentation

Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children. This was presented during a Critical Care Reviews Livestream event.

Papers

FIRST-ABC (Step-Up)

FIRST-ABC (Step Down)

CCR Trial Summaries & Critiques

FAST Trial

added April 18th

Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia

HI-PEITHO Trial

added March 28th

Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute PE

PRONTO Trial

added March 24th

Procalcitonin testing combined with NEWS2 evaluation in sepsis

Journal Watch Latest

Journal Watch

Newsletter

RCT

Neyra. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial. Lancet Respir Med 2026;epublished March 23rd

added March 24th

image: Shutterstock / KILO LUX

RCT

Todd. Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Respir Med 2026;epublished March 22nd

added March 24th

image: Shutterstock / Saiful52

RCT

Semple. Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial. Lancet Respir Med 2026;epublished March 21st

added March 24th

image: Shutterstock / mindfullness

Observational Study

Reddy. Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study. Lancet Respir Med 2026;epublished March 23rd

added March 24th

image: Shutterstock / kalewa

Guideline

Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM). Intensive Care Med 2026;epublished March 24th

added March 24th

image: Shutterstock / Retrofernz

Guideline

Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Crit Care Med 2026;epublished March 23rd

added March 24th

image: SSC logo

Guideline

Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Intensive Care Med 2026;epublished March 23rd

added March 23rd

image: Shutterstock / BelezaPoy

RCT

Tavoulareas. Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial. Lancet Reg Health Eur 2026;62:101573

added February 18th

image: Shutterstock / Karan Bunjean

CT brain showing a large intra cerebral haemorrhage

Commentary

Sekhon. Hyperoxaemia in acute brain injured patients: too much of a good thing?. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock / Yok_onepiece

Narrative Reviews

Joosten. Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidence. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock /

Foundational Trials Collection

After many months of preparation, we're delighted to release our Foundational Trials Collection.

250 critical care contemporary trials are summarised and critiqued in depth.

If you are new to the field, are undertaking exams, or just want to refresh your knowledge, this is an excellent place to start.

added February 17th

Sample Summaries

ARMA

Low tidal volume ventilation
HEMOTION

Transfusion thresholds in TBI
IABP-SHOCK II

Intraaortic balloon pump for myocardial infarction with cardiogenic shock
SAFE

Albumin vs Saline in ICU
ADRENAL

Hydrocortisone for septic shock
REVISE

PPI for gastric ulcer prophylaxis
RSI

Ketamine vs etomidate for rapid sequence intubation
BLING III

Beta lactam infusions in sepsis

CCR Content

Paper of the Day

Pan. Therapy of Aspiration: Out-of-Hospital and In-Hospital-Acquired. Semin Respir Crit Care Med 2024;45(6):701-708

added Monday April 20th

Foundational Trial Summary & Critique

Semler. Balanced Crystalloids versus Saline in Critically Ill Adults (SMART). N Engl J Med 2018;378:829-839

added March 24th

Empty operating room, in a blurred focus

Major Trial Summary & Critique

Sonneville R, Couffignal C, Sigaud F, et al; R2D2-ICU Investigator Study Group. Restrictive vs liberal physical restraint strategies in critically ill patients: the R2D2-ICU randomized clinical trial. JAMA 2026;epublished March 17th

added March 24th

CCR26

The Best Critical Care Trials in the World

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR22 | FIRST-ABC Trial

FIRST-ABC (Step Down) Trial Presentation

Papers

CCR Trial Summaries & Critiques

FAST Trial

HI-PEITHO Trial

PRONTO Trial

Journal Watch Latest

RCT

RCT

RCT

Observational Study

Guideline

Guideline

Guideline

RCT

Commentary

Narrative Reviews

Foundational Trials Collection

Sample Summaries

CCR Content

Paper of the Day

Latest Newsletter

Highlighted Guideline

Foundational Trial Summary & Critique

Major Trial Summary & Critique

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