Latest Trial Summaries & Critiques

August

PRAGUE-26

Kroupa J, Radvan M, Mrozek J, et al. Catheter-directed thrombolysis in intermediate-high–risk pulmonary embolism. N Engl J Med 2026;epublished August 31st

added August 31st

CHIPS

Spinella PC, Zantek ND, VanBuren JM, et al; CHIPS Investigator Group. Cold and room-temperature platelets in cardiac surgery: the CHIPS randomized clinical trial. JAMA 2026;epublished August 17th.

added August 18th

Bielicki. Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial. Lancet. 2026;408(10554):545–557.

added August 13th

Ampoule containing pneumococcal vaccine being aspirated

VACIRiSS

Shankar-Hari. A randomized, placebo-controlled trial of 13-valent pneumococcal conjugate vaccination to accelerate immune recovery after sepsis. Sci Transl Med. 2026;18(862):eaeb4113.

added August 13th

Patient having an operation under general volatile anaesthesia

VITAL

Jhanji. Total intravenous vs volatile inhalational anesthesia for major noncardiac surgery: a randomized clinical trial. JAMA. Published online August 12, 2026.

added August 13th

Patient being intubated with a video laryngoscope

COVALENT

Schmid. Conventional vs video-assisted laryngoscopy for perioperative endotracheal intubations: a randomized clinical trial. JAMA Netw Open. 2026;9(8):e2625965

added August 8th

SAVE-O2

Douin. Autonomous oxygen titration for maintaining normoxemia in acutely ill adults: the SAVE-O2 AI randomized clinical trial. JAMA Intern Med 2026;epublished August 3rd

added August 8th

Invasively ventilated patient in the ICU

ICECAP

Meurer. Duration of therapeutic hypothermia after out-of-hospital cardiac arrest: the ICECAP randomized clinical trial. JAMA 2026;epublished August 5th

added August 6th

July

PROPOSITIS

Baudin. Prone Positioning in Infants With Acute BronchiolitisThe PROPOSITIS Randomized Clinical Trial. JAMA 2026;336(4):315-322

added July 29th

PAEAN

Liley. Erythropoietin for neonatal hypoxic-ischemic encephalopathy: a randomized clinical trial. JAMA Pediatr. 2026;epublished July 27th.

added July 28th

Patient undergoing a stroke thrombectomy

DISCOUNT

Clarençon. Mechanical thrombectomy in ischemic stroke with a medium or distal arterial occlusion: the DISCOUNT randomized clinical trial. JAMA. 2026;epublished July 22nd.

added July 26th

RATE

van Minnen O, Oude Lansink-Hartgring A, van Amstel RBE, van den Bogaard B, Bunge JJH, Delnoij TSR, et al. Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial. Lancet. 2026;epublished July 8th

added July 8th

DigiSep

Brenner T, Skarabis A, Schaller SJ, von Groote T, Putensen C, Günther U, et al. Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial. Intensive Care Med. 2026;epublished June 30th.

added July 1st

June

HISTAP

Cecconi M, Cortegiani A, Noto A, Sotgiu G, Antonelli M, Anderloni M, et al. HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial. Intensive Care Med. 2026;epublished June 29th

added June 29th

REBOARREST

Brede JR, Farbu BH, Gamberini L, Thorsen K, Rehn M, Rognås L, et al. Prehospital resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest (REBOARREST): an international, multicentre, open label, pragmatic, randomised, controlled trial. Crit Care 2026;30:324.

added June 28th

TRACTION

Houston BL, McIsaac DI, Breau RH, Kanji S, Greenstreet P, Andrews M, et al. Hospital policy of tranexamic acid to reduce transfusion in major noncardiac surgery. N Engl J Med 2026;epublished June 10th

added June 20th

SNAP - Cephazolin

Lee TC, Barina LA, Walls G, et al; Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Cefazolin for methicillin-susceptible Staphylococcus aureus bacteremia. N Engl J Med. 2026;394:2329-2339

added June 18th

SNAP - Benzylpenicillin

The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial. Lancet. 2026; published online June 17

added June 18th

Ampoules of intravenous vitamin C beside some oranges

VITaCCA

Rozemeijer S, Dubois EA, de Grooth HJ, den Uil CA, Rettig TCD, Rijpstra TA, et al. Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial. Intensive Care Med 2026;epublished June 16th.

added June 17th

GASTRIC-PICU

Tume LN, Mouncey PR, Broomhall JM, et al; GASTRIC-PICU Investigators of the Paediatric Critical Care Society Study Group. Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial. JAMA. Published online June 12, 2026.

added June 18th

Ventilated ICU patient with CCRT machine alongside

SODa-BIC

The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Sodium bicarbonate for critically ill adults with metabolic acidosis and shock. N Engl J Med 2026;epublished June 12th

added June 14th

Post ICU patient receiving rehabilitation at home

ACCOMPLISH

Yende S, Talisa VB, Mayes K, et al. Remote Monitoring Approaches to Reduce Readmissions After Infection and Sepsis: A Randomized Clinical Trial. JAMA Netw Open. 2026;9(6):e2616641

added June 18th

BIHCA

Granfeldt A, Kirkegaard BL, Vallentin MF, Holmberg MJ, Stankovic N, Lind PC, et al; Bicarbonate for In-Hospital Cardiac Arrest (BIHCA) Investigators. Sodium bicarbonate for in-hospital cardiac arrest: a randomized clinical trial. JAMA. Published online June 11, 2026.

added June 18th

ARISE-FLUIDS

The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network. Vasopressors or fluids in early septic shock. N Engl J Med 2026;epublished June 11th

added June 18th

Ventilated ICU patient with a tracheostomy tube

TELE-REHAB

Rosa RG, Moraes RB, Trott G, et al; Tele-Rehab Trial Group. Integrated telehealth rehabilitation and quality of life in mechanically ventilated adults: a randomized clinical trial. JAMA. Published online June 10, 2026.

added June 18th

VICTORY

Stoppe C, Hill A, Cancio LC, et al; VICTORY Study Team. High-dose intravenous vitamin C and mortality and organ dysfunction in severe burn injury: the VICTORY randomized clinical trial. JAMA. Published online June 10, 2026.

added June 18th

MARCH

Connolly B, Dickson N, Campbell C, et al; MARCH Trial Investigators. Carbocisteine or hypertonic saline for acute respiratory failure. N Engl J Med. Published online June 10, 2026.

added June 18th

LOGICAL

The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Conservative oxygen for unresponsive patients after cardiac arrest. N Engl J Med 2026;epublished June 10th

added June 18th

MICROINHALO

De Pascale G, Cutuli SL, Vargas M, Cortegiani A, Dalfino L, Greco M, et al. Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial. Intensive Care Med 2026;epublished June 2nd

added June 18th

May

Family member holding the hand of a patient

FICUS

Riguzzi M, Jeitziner MM, Rufer M, von Felten S, Verweij L, Oesch S, et al. The FICUS cluster randomized controlled trial of a family support intervention in adult intensive care units: mental health and family functioning outcomes. Intensive Care Med 2026;epublished May 18th

added May 19th

Patient undergoing rehabilitation at home

iRehab

O’Neill B, Bradley JM, Connolly B, Bruce J, Ratna M, Lall R, et al; iRehab Trial Investigators. Remote multicomponent rehabilitation in intensive care unit survivors: a randomized clinical trial. JAMA 2026;epublished May 18th

added May 18th

Fluids being given in a helicopter transfer

TOWAR

Sperry JL, Guyette FX, Cotton BA, Luther JF, Utarnachitt RB, Kutcher ME, et al; TOWAR Study Group. Prehospital resuscitation with type O whole blood for trauma and hemorrhage. N Engl J Med 2026;epublished May 18th

added May 18th

Right internal juglar central venous catheter

CLiCK

Ornowska. 4% tetrasodium EDTA to prevent central venous access device–associated complications: a randomized clinical trial. JAMA 2026;epublished May 18th

added May 18th

Patient undergoing a stroke thrombectomy in the interventional radiology suite

ORIENTAL-MeVO

Hu W, Jing X, Chen Z, Zheng J, Yi T, Zheng T, et al. Endovascular treatment of medium-vessel-occlusion strokes. N Engl J Med. 2026;394(19):1894-904

added May 17th

OkyKids

Louman S, van Stralen KJ, Koppelman GH, Vaessen-Verberne AAPH, Bekhof J, Bosmans JE, et al. Oxygen saturation thresholds in children with acute respiratory distress (OxyKids): a multicentre, open, parallel-group, randomised clinical trial. Lancet Respir Med 2026;epublished May 12th

added May 14th

People protesting that ivermectin is beneficial in COVID-19

Ivermectin for COVID-19

Hashmi M, Haniffa R, Jayakumar D, Beane A, Lorenzi E, Berry LR, et al; REMAP-CAP Investigators. Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP). Crit Care Med 2026;epublished May 8th

added May 9th

Stroke thrombectomy in the interventional suite

TNK-PLUS

Xiong Y, Che F, Wang H, et al; TNK-PLUS Investigators. Intravenous tenecteplase prior to endovascular treatment for ischemic stroke at 4.5 to 24 hours: the TNK-PLUS randomized clinical trial. JAMA 2026;epublished May 8th

added May 8th

Stroke patient receiving a tirofiban infusion

INSTANT

INSTANT Trial Authors for the INSTANT Investigators. Intravenous tirofiban after tenecteplase in acute ischemic stroke: the INSTANT randomized clinical trial. JAMA 2026;epublished May 8th

added May 8th

April

5 different IV fluid containers hanging in theatre

PROMPT-BOLUS

Balamuth F, Weiss SL, Long E, et al. Balanced fluid or 0.9% saline in children treated for septic shock. N Engl J Med 2026;epublished April 23rd

added April 24th

Latest Trial Summaries & Critiques

August

PRAGUE-26

CHIPS

PediCAP

VACIRiSS

VITAL

COVALENT

SAVE-O2

ICECAP

July

PROPOSITIS

PAEAN

DISCOUNT

RATE

DigiSep

June

HISTAP

REBOARREST

TRACTION

SNAP - Cephazolin

SNAP - Benzylpenicillin

VITaCCA

GASTRIC-PICU

SODa-BIC

ACCOMPLISH

BIHCA

ARISE-FLUIDS

TELE-REHAB

VICTORY

MARCH

LOGICAL

MICROINHALO

May

FICUS

iRehab

TOWAR

CLiCK

ORIENTAL-MeVO

OkyKids

Ivermectin for COVID-19

TNK-PLUS

INSTANT

April

PROMPT-BOLUS

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