Narrative Reviews
Direct Oral Anticoagulants
Image: Shutterstock / Sonis Photography
Major Haematology Trials | Major Haematology Guidelines
General
General
General
Background
Pathophysiology
Conditions
Gastrointestinal Bleeding
Intracerebral Haemorrhage
- Seiffge. Reversal of anticoagulation in patients with intracerebral haemorrhage related to oral anticoagulants: State of the evidence. Eur Stroke J. 2025;10(1 Suppl):14-23.
- Christensen. Principles of reversal of anticoagulation in patients with intracerebral hemorrhage related to oral anticoagulants. Eur Stroke J. 2025;10(1 Suppl):4-13.
- Yang. Reversal and resumption of anticoagulants in patients with anticoagulant-associated intracerebral hemorrhage. Eur J Med Res. 2024;29(1):252.
Complications
Complication
- Zheng. From empirical hemostasis to precision reversal: clinical challenges, technological innovations, and individualized strategies in anticoagulant-associated bleeding. Front Cardiovasc Med. 2026;13:1846208.
- Al Aseri. Evidence-based Management of Major Bleeding in Patients Receiving Direct Oral Anticoagulants: An Updated Narrative Review on the Role of Specific Reversal Agents. J Cardiovasc Pharmacol Ther. 2023;28:10742484231202655.
Monitoring & Investigations
General
Therapies
Reversal
- Berger. Expert Opinion on Implementing Oral Anticoagulation Reversal Protocols in US Hospitals. Clin Appl Thromb Hemost. 2026;32:10760296261442058.
- Bekka. Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine). Br J Clin Pharmacol. 2025;91(3):604-614.
- Falanga. Reversal of oral anticoagulation in emergency conditions. Blood Transfus. 2025;23(1):64-69.
Factor XI Inhibitors
Last updated August 4th, 2026


