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Critical Care Reviews Newsletter
Newsletter 599 | June 4th, 2023
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Just a Week to CCR23
Welcome to the 599th Critical Care Reviews Newsletter and the end of an era for us. Sadly, after 11 years and 599 consecutive issues, this will be our last free newsletter. If you wish to continue receiving it, please subscribe - the cost is relatively low and will help fund our work. If you are from a low or low-middle income country, please
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The highlights of this week's edition are randomised controlled trials on thoracic epidural analgesia in ICU patients with acute pancreatitis & nangibotide, a TREM-1 inhibitor, in patients with septic shock; systematic reviews and meta analyses on high-normal versus low-normal mean arterial pressure thresholds in critically ill patients & the efficacy of CytoSorb; and observational studies on ventilator-associated pneumonia in neurocritically ill patients & clinical outcomes of intensive inpatient blood pressure management in hospitalized older adults.
There are also guidelines on mechanical circulatory support & acute heart failure and valvular heart disease; narrative reviews on right ventricular dysfunction in patients with ARDS receiving venovenous ECMO & fluid management in patients with septic shock; editorials on veno-pulmonary arterial ECMO in severe ARDS & how could ChatGPT impact my practice as an intensivist?; and commentaries on adjunctive vasopressors in distributive shock & normothermic regional perfusion in organ transplantation.
If you only have time to read one review article this week, try this one on hemodynamic and respiratory support in pulmonary embolism.
Critical Care Reviews Meeting 2023
There is just over a week until the Critical Care Reviews Meeting 2023 in Titanic Belfast, Northern Ireland. There is still room for late registrations. If you can't make it to Belfast, you can watch online for free, or take the paid option for 18 CPD/CME points. With no fewer than 7 major trial results presentations, 6 reviews of some of the best trials of the past year, two panel discussions and the John Hinds Lecture, it promises to be a superb event.
Research
Randomised Controlled Trials
- Jabaudon. Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial. Crit Care 2023;27:213
- François. Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial. Lancet Respir Med 2023;epublished May 31st
- Vourc'h. High-flow oxygen therapy versus facemask preoxygenation in anticipated difficult airway management (PREOPTI-DAM): an open-label, single-centre, randomised controlled phase 3 trial. EClinicalMedicine 2023;60:101998
- Zi. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion. N Engl J Med 2023;388:2025-2036
- Vacheron. Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial. J Crit Care 2023;78:154330
- Agaewal. Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure. J Hepatol 2023;epublished May 31st
- Cheng. Data-informed debriefing for cardiopulmonary arrest: A randomized controlled trial. Resusc Plus 2023;14:100401
- Lu. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial. Lancet 2023;epublished May 25th
Systematic Review & Meta Analyses
- Rikhraj. High-normal versus low-normal mean arterial pressure thresholds in critically ill patients: a systematic review and meta-analysis of randomized trials. Can J Anaesth 2023;epublished June 2nd
- Ding. Effect of Sivelestat in the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Intensive Care Res 2023;epublished June 1st
- Jones. Responsiveness of Critically Ill Adults With Multimorbidity to Rehabilitation Interventions: A Patient-Level Meta-Analysis Using Individual Pooled Data From Four Randomized Trials. Crit Care Med 2023;epublished May 29th
- Becker. Efficacy of CytoSorb®: a systematic review and meta-analysis. Crit Care 27, 215 (2023)
- He. Aggressive versus controlled fluid resuscitation in acute pancreatitis: A systematic review and meta-analysis of randomized controlled trials. Chin Med J 2023;136:1166-1173
- Xu. Comparison of High Flow Nasal Therapy with Non-Invasive Ventilation and Conventional Oxygen Therapy for Acute Hypercapnic Respiratory Failure: A Meta-Analysis of Randomized Controlled Trials. Int J Chron Obstruct Pulmon Dis 2023;18:955-973
Observational Studies
- Andrea. Pulseless Electrical Activity and Asystole During In-Hospital Cardiac Arrest: Disentangling the 'Nonshockable' Rhythms. Resuscitation 2023;epublished June 1st
- Fatnic. Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study. Lancet Respir Med 2023;11(6):520-529
- Emeriaud. Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study. Pediatr Crit Care Med 2023;epublished May 31st
- Colombo. Failing categorization of severe COVID-19 ARDS into ventilatory subphenotypes studied via the clinical-histopathologic relationship. Respir Med 2023;epublished May 30th
- Foucrier. Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial. Crit Care 2023;27:211
- Turan. Association Between Mobilization and Composite Postoperative Complications Following Major Elective Surgery. JAMA Surg 2023;epublished May 31st
- Battaglini. Ventilator-associated pneumonia in neurocritically ill patients: insights from the ENIO international prospective observational study. Respir Res 2023;24:146
- Hernández-García. Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study. Life 2023;13:1207
- Anderson. Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults. JAMA Intern Med 2023;epublished May 30th
- Black. Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK. Crit Care 2023;27:217
- Fiore. Risks and benefits of animal-assisted interventions for critically ill patients admitted to intensive care units. J Anesth Analg Crit Care 2023;3:15
- Zampieri. Conditional Treatment Effect Analysis of Two Infusion Rates for Fluid Challenges in Critically Ill Patients: A Secondary Analysis of Balanced Solution versus Saline in Intensive Care Study (BaSICS) Trial. Ann Am Thorac Soc 2023;20:767-780
Protocols
- Young. Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with sepsis in the intensive care unit (Mega-ROX Sepsis). Crit Care Resusc 2023;epublished May 22nd
- Young. Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains). Crit Care Resusc 2023;25(1):53-59
- George. Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a statistical analysis plan for a randomised controlled trial. Trials 2023;24(1):369
Guidelines
- The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update. J Heart Lung Transplant 2023;epublished May 25th
- Acute Heart Failure and Valvular Heart Disease: A Scientific Statement of the Heart Failure Association (HFA), the Association for Acute Cardi-Vascular Care (ACVC) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. Eur J Heart Fail 2023;epublished May 23rd
- Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus. Mil Med Res 2023;10(1):23
- Faletra. Three-dimensional transoesophageal echocardiography: how to use and when to use—a clinical consensus statement from the European Association of Cardiovascular Imaging of the European Society of Cardiology. Eur Heart J Cardiovasc Imaging 2023;epublished June 1st
- Current vision on diagnosis and comprehensive care in hepatic encephalopathy. Rev Gastroenterol Mex 2023;88(2):155-174
- Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2023;20(6)
Reviews
Clinical
Neurological
- Klawitter. Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions. Medicina 2023;59:844
- Bircak-Kuchtova. Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?. Crit Care 2023;27:214
- Czarniak. Cerebrospinal Fluid-Basic Concepts Review. Biomedicines 2023;11:1461
Circulatory
- Moady. Sodium-Glucose Co-Transporter 2 Inhibitors in Heart Failure—Current Evidence in Special Populations. Life 2023;13:1256
- Brown. Right ventricular dysfunction in patients with acute respiratory distress syndrome receiving venovenous extracorporeal membrane oxygenation. Front Cardiovasc Med 2023;epublished May 17th
- Knežević. Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications. J Cardiovasc Dev Dis 2023;10:213
Respiratory
- Götzinger. Interventional therapies for pulmonary embolism. Nat Rev Cardiol 2023;epublished May 14th
- Santus. Acute dyspnea in the emergency department: a clinical review. Intern Emerg Med 2023;epublished June 2nd
- Yu. Update on transfusion-related acute lung injury: an overview of its pathogenesis and management. Front Immunol 2023;epublished May 12th
- Zadeh. B-mode ultrasound and contrast-enhanced ultrasound for evaluation of pneumonia: A pictorial essay. JUM 2023;26:(2)
- Cousin. Use of CO2-Derived Variables in Cardiac Intensive Care Unit: Pathophysiology and Clinical Implications. J Cardiovasc Dev Dis 2023;10:208
- Crimi. Lessons from COVID-19 in the management of acute respiratory failure. Breathe 2023;19:230035
- Cordeiro. Oxygen in interstitial lung diseases. Breathe 2023;19:220271
- Pérez-Nieto. Hemodynamic and respiratory support in pulmonary embolism: a narrative review. Front Med 2023;10:1123793
Hepatobiliary
Renal
Endocrine
Sepsis
- Moschopoulos. New Insights into the Fluid Management in Patients with Septic Shock. Medicina 2023;59:1047
- Waters. Bloodstream Infection and Gram-Negative Resistance: The Role for Newer Antibiotics. Antibiotics 2023;12:977
- Thy. Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens. Antibiotics 2023;12:860
- Legg. Beta-Lactam Dose Optimisation in the Intensive Care Unit: Targets, Therapeutic Drug Monitoring and Toxicity. Antibiotics 2023;12:870
- Alves. Antimicrobial Stewardship on Patients with Neutropenia: A Narrative Review Commissioned by Microorganisms. Microorganisms 2023;11:1127
Trauma
Toxicology
Paediatrics
Miscellaneous
Editorials
- Zochios. Veno-Pulmonary Arterial Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Should We Consider Mechanical Support of the Pulmonary Circulation From the Outset? ASAIO J 2023;69(6):511-518
- Komorowski. How could ChatGPT impact my practice as an intensivist? An overview of potential applications, risks and limitations. Intensive Care Med 2023;epublished May 31st
Commentaries
Correspondence
- Jiang. The cephalic vein access for use in intensive care unit: an alternative approach. Crit Care 2023;27:209
- Hansel. Propofol versus the world: The whole is not always greater than the sum of its parts. Crit Care 2023;27:208
- Bianchi. Identification of an optimal threshold to define oliguria in critically ill patients: an observational study. Crit Care 2023;27:207
- Lee. Nutrition during the acute phase of critical illness: discussions on NUTRIREA-3. Lancet Respir Med 2023;epublished May 24th
- Patel. Nutrition during the acute phase of critical illness: discussions on NUTRIREA-3. Lancet Respir Med 2023;epublished May 24th
- Wernly. Improving frailty assessment: the task is not finished. Crit Care 2023;27:218
- Camarda. The stroke care puzzle: Does tracheostomy timing fit?. Crit Care 2023;27:216
- Massart. Dichotomy between ventilator-associated pneumonia/-tracheobronchitis: did you ask the lung its opinion?. Intensive Care Med 2023;epublished May 31st
- Bradbury. Continuation of therapeutic dose heparin for critically ill patients with COVID-19. Intensive Care Med 2023;epublished May 31st
Case Reports
- Chaudhary. Management of airway obstruction following lidocaine nebulization in a case of tracheal stenosis: case report. Braz J Anesthesiol 2023;73(3):351-353
- Balaini. Central pontine myelinolysis. QJM: An International Journal of Medicine, Volume 116, Issue 5, May 2023, Page 381
- Yuan. Anticoagulation-free Extracorporeal Membrane Oxygenation in Severe Bronchial and Lung Trauma. J Cardiothorac Vasc Anesth 2023;37(7):1250-1254
- Nondo. Fatal case of Capnocytophaga sepsis from a dog bite in a patient with splenic hypoplasia. Accute Med Surg 2023;10(1):e849
- Shirahige. Cerebral venous thrombosis in a young man. Acute Med Surg 2023;10(1):e853
- Saxena. Chylous cardiac tamponade. J Cardiothorac Vasc Anesth 2023;epublished May 29th
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Until next week
Rob