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Critical Care Reviews Newsletter
Newsletter 589 | March 26th, 2023
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PATCH-Trauma trial results to be presented at CCR23
Welcome to the 589th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on anticoagulation in patients with hypoxemic COVID-19 pneumonia and the neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury; systematic reviews and meta analyses on the diagnostic yield of CT head in delirium and altered mental status & prophylactic inferior vena cava filters for venous thromboembolism in adults with trauma; and observational studies on intracranial pressure monitoring vs no monitoring in severe penetrating brain injury & osmotic demyelination syndrome in patients hospitalized with hyponatremia.
There are also guidelines on neuroprognostication in adults with Guillain–Barré Syndrome & prehospital haemorrhage control; narrative reviews on personalized fluid therapy in septic shock & temperature control after cardiac arrest; editorials on mechanical cardiopulmonary resuscitation during in-hospital cardiac arrest & catheter-related thromboses in critically ill patients; and commentaries on antifungal stewardship in critically ill patients & whether the U-shaped curve is still of relevance to the oxygenation of critically ill patients.
If you only have time to read one review article this week, try this one on prehospital tranexamic acid for trauma victims. Or, you could try some of the fantastic 10 articles from the Annual Update in Intensive Care and Emergency Medicine 2023, released to coincide with the Brussels ISICEM congress. If you missed the trials presented at Brussels, they were included in a supplementary Critical Care Reviews Newsletter at the start of the week.
Latest Trial Result Presentation at CCR23
We're delighted to announce that the results of the Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage trial (PATCH-Trauma) will be presented by Prof Russell Gruen (Canberra, Australia) at CCR23 in June. Thirteen years after the CRASH-2 trial was published, there will soon be some answers to its perceived limitations. Is pre-hospital tranexamic acid beneficial in patients with severe trauma and at risk for acute traumatic coagulopathy? Join us in June to find out!
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Research
Randomised Controlled Trials
- Beqiri. Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study. Crit Care 2023;27:115
- Talasaz. Atorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial. Thromb Haemost 2023;epublished March 21st
- Labbe. Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia. The ANTICOVID Randomized Clinical Trial. JAMA Intern Med 2023;epublished March
- Wichmann. Goal-directed fluid removal with furosemide versus placebo in intensive care patients with fluid overload: A randomised, blinded trial (GODIF trial-First version). Acta Anaesthesiol Scand 2023;67(4):470-478
Systematic Review & Meta Analyses
- Zitikyte. Pharmacologic Interventions to Prevent Delirium in Trauma Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Crit Care Explor 2023;5(3):e0875
- Akhtar. Diagnostic yield of CT head in delirium and altered mental status - A systematic review and meta-analysis. J Am Geriatr Soc 2023;71(3):946-958
- Li. Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis. Critical Care 2023 27:122
- Alshaqaq. Prophylactic Inferior Vena Cava Filters for Venous Thromboembolism in Adults With Trauma: An Updated Systematic Review and Meta-Analysis. J Intensive Care Med 2023;epublished March 20th
- Al Lawati. Early Versus Delayed Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation—A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Explor 2023;5(3):0874
Observational Studies
- Ali Mansour. Comparative Effectiveness of Intracranial Pressure Monitoring vs No Monitoring in Severe Penetrating Brain Injury Management. JAMA Netw Open 2023;6(3):e231077
- MacMillan. Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia. N Engl J Med 2023;epublished March 23rd
- Sarigul. Prognostication and Withdrawal of Care Decisions in Severe Traumatic Brain Injury: A Survey of The Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) Working Group. J Neurotrauma 2023;epublished March 18th
- Ford. Cardiac Arrest During Delivery Hospitalization. A Cohort Study. Ann Intern Med 2023;epublished March 14th
- Tiruvoipati. Extracorporeal Carbon Dioxide Removal With the Hemolung in Patients With Acute Respiratory Failure: A Multicenter Retrospective Cohort Study. Crit Care Med 2023;epublished March 21st
- Huang. Association of Sublingual Microcirculation Parameters and Capillary Refill Time in the Early Phase of ICU Admission. Crit Care Med 2023;epublished March 21st
- Denny. Diagnosing sepsis in the ICU: Comparison of a gene expression signature to pre-existing biomarkers. J Crit Care 2023 Mar 23;76:154286
Protocols
- Blok. Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE): protocol for a multicentre randomised controlled trial. Trials 2023;24(1):226
- Arleth. Comparing Restrictive vs. Liberal Oxygen Strategies for Trauma Patients: The TRAUMOX2 Trial - Statistical Analysis Plan. Acta Anaesthesiol Scand 2023;epublished March 11th
- Azamfirei. Impact of a multifaceted early mobility intervention for critically ill children — the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial. Trials 2023;24:191
Guidelines
- Busl. Guidelines for Neuroprognostication in Adults with Guillain–Barré Syndrome. Neurocrit Care 2023;epublished March 25th
- Vega. Nutritional management of children with acute kidney injury—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce. Pediatr Nephrol 2023;epublished March 20th
- Berry. Prehospital Hemorrhage Control and Treatment by Clinicians: A Joint Position Statement. Prehosp Emerg Care 2023;epublished March 22nd
Reviews
Clinical
COVID-19
Neurological
- Wulf. Consequences of spinal cord injury on the sympathetic nervous system. Front Cell Neurosci. 2023;17:999253
- Benedetti. Review of Noninvasive Neuromonitoring Modalities in Children II: EEG, qEEG. Neurocrit Care 2023;epublished March 22nd
- Ko. Advanced Neuromonitoring Modalities on the Horizon: Detection and Management of Acute Brain Injury in Children. Neurocrit Care 2023;epublished March 22nd
- Müller. Non-Invasive Intracranial Pressure Monitoring. J Clin Med 2023;12(6):2209
- Roman-Filip. Non-Aneurysmal Perimesencephalic Subarachnoid Hemorrhage: A Literature Review. Diagnostics 2023;13:1195
Circulatory
- Yin. Hemodynamic Management During Veno-Arterial Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock: A Review. Intensive Care Res 2023;epublished March 20th
- Acharya. Aortic valve disorders and left ventricular assist devices. Front Cardiovasc Med 2023; 10:1098348
- Di Nicolò. Inferior Vena Cava Ultrasonography for Volume Status Evaluation: An Intriguing Promise Never Fulfilled. J Clin Med 2023;12(6):2217
- McIntyre. Post-operative atrial fibrillation after cardiac surgery: Challenges throughout the patient journey. Front Cardiovasc Med 2023;10:1156626
- Gaudino. Postoperative atrial fibrillation: from mechanisms to treatment. Eur Heart J 2023;44(12):1020–1039
- Dagher. Transcatheter valvular therapies in patients with left ventricular assist devices. Front. Cardiovasc Med 2023;10:1071805
Resuscitation
Respiratory
- Asllanaj. Fluid management in septic patients with pulmonary hypertension, review of the literature. Front Cardiovasc Med 2023;10:1096871
- Bittner. Acute Respiratory Distress Syndrome, Mechanical Ventilation, and Inhalation Injury in Burn Patients. Surg Clin North Am 2023;epublished March 20th
- Rizzo. The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome. Am J Physiol Cell Physiol 2023;324(4):C799-C806
- Liang. Perioperative Circulatory Support and Management for Lung Transplantation: A Case-Based Review. Sem Cardiothorac Vasc Anesth 2023;27(1):68-74
- Owens. Supplemental oxygen and noninvasive ventilation. Eur Respir Rev 2023;32(167):220159
- Cullivan. New trends in pulmonary hypertension. Eur Respir Rev 2023;32:220211
- Batchelor. Enhanced recovery after surgery and chest tube management. J Thorac Dis 2023;15(2):901-908
Gastrointestinal
Hepatobiliary
- Hosack. Drug-induced liver injury: a comprehensive review. Ther Adv Gastroenterol 2023;16:1–13
- Melenotte. Invasive aspergillosis in liver transplant recipients. Transplant Infect Dis 2023;epublished March 16th
Haematological
Sepsis
- Monnet. How I personalize fluid therapy in septic shock?. Crit Care 2023;27:123
- França. The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies. Antibiotics 2023;12:554
Trauma
Paediatrics
Obstetrics
Perioperative
- Cios. Managing Diastolic Dysfunction Perioperatively. Semin Cardiothorac Vasc Anesth 2023;27(1):42-50
- Ma. Multimodal Analgesia and Intraoperative Neuromonitoring. J Neurosurg Anesthesiol 2023;35(2):172-176
- Rengel. Perioperative Neurocognitive Disorders in Adults Requiring Cardiac Surgery: Screening, Prevention, and Management. Semin Cardiothorac Vasc Anesth 2023;27(1):25-41
Miscellaneous
Pre-Clinical
- Scaramuzzo. Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance. J Inflamm 2023;20:11
- Areny-Balagueró. Bioengineered extracellular vesicles: future of precision medicine for sepsis. ICMx 2023;11:11
- Ning. Targeting immunometabolism against acute lung injury. Clin Immunol 2023;epublished March 12th
- Wang. MicroRNAs in septic acute kidney injury. Burns Trauma 2023;11:tkad008
Annual Update in Intensive Care and Emergency Medicine 2023
- Lai. Hemodynamic Implications of Prone Positioning in Patients with ARDS. Crit Care 2023;27:98
- Turgman. Host Response Biomarkers for Sepsis in the Emergency Room. Crit Care 2023;27:97
- Lewis. Quality improvement in the determination of death by neurologic criteria around the world. Crit Care 2023;27:96
- Assouline. Setting and Monitoring of Mechanical Ventilation During Venovenous ECMO. Crit Care 2023;27:95
- Bos. A structured diagnostic algorithm for patients with ARDS. Crit Care 2023;27:94
- Lindell. Interrogating the sepsis host immune response using cytomics. Crit Care 2023;27:93
- Abe. Update on the management of acute respiratory failure using non-invasive ventilation and pulse oximetry. Crit Care 2023;27:92
- Jabaley. Managing the Physiologically Difficult Airway in Critically Ill Adults. Crit Care 2023;27:91
- Neyton. Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses. Crit Care 2023;27:90
- Pelaia. The Role of Transcriptomics in Redefining Critical Illness. Crit Care 2023;27:89
Veterinary Medicine
Editorials
- Mitchell. Mechanical Cardiopulmonary Resuscitation During In-Hospital Cardiac Arrest. J Am Heart Assoc 2023;epublished March 21st
- Brescia. The SIC protocol: A seven-step strategy to minimize complications potentially related to the insertion of centrally inserted central catheters. J Vasc Access 2023;24(2):185-190
- Lewis. How Can International Consistency in Determination of Brain Death/Death by Neurological Criteria be Improved? The World Brain Death Project. J Neurosurg Anesthesiol 2023;35(2):169-171
- Ma. Multimodal Analgesia and Intraoperative Neuromonitoring. J Neurosurg Anesthesiol 2023;35(2):172-176
- Helms. Catheter-related thromboses in critically ill patients: are they worth looking for?. Intensive Care Med 2023;epublished March 24th
- Ware. Improving ARDS Diagnosis: Is Lung Ultrasound the Answer? Am J Respir Crit Care Med 2023;epublished March 21st
Commentaries
- De Pascale. Antifungal stewardship in critically ill patients. Intensive Care Med 2023;epublished March 24th
- Gandini. Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era. Crit Care 2023;27:124
- Beaulieu. Evidence-based medical therapy for the treatment of critically ill COVID-19 patients: A primer for cardiologists. Can J Cardiol 2023;epublished March 23rd
- Trent. Create intensive care green teams, there is no time to waste. Intensive Care Med 2023;epublished March 23rd
- Nassar. Long-term outcomes of intensive care unit delirium. Intensive Care Med 2023;epublished March 24th
- Zampieri. Admission to intensive care unit after major surgery. Intensive Care Med 2023;epublished March 22nd
- Martin. Is the U-shaped curve still of relevance to oxygenation of critically ill patients? Intensive Care Med 2023;epublished March 21st
- Vincent. Sepsis and infection: Two words that should not be confused. Front Med 2023;10:1156732
- Radecki. Usual Care, Unusual Care, and the Lessons From CLOVERS. Ann Emerg Med 2023;81(4):513-515
- Ioannidis. The Rapid Growth of Mega-Journals. Threats and Opportunities. JAMA 2023;epublished March 20th
Correspondence
- Cuyas. WEAN SAFE and the definition of the first separation attempt. Lancet Respir Med 2023;epublished March 16th
- Drinhaus. W(h)at(t) counts in electricity consumption in the intensive care unit. Intensive Care Med 2023;epublished March 23rd
- Stahl. Innovative future concepts of extracorporeal strategies in sepsis and septic shock. Crit Care 2023;27:121
- Azamfirei. Large language models and the perils of their hallucinations. Crit Care 2023;27:120
- Pérez. Patient Self-inflicted and Ventilator-induced Lung Injury: Two Sides of the Same Coin? Am J Respir Crit Care Med 2023;epublished March 23rd
Case Reports
I hope you find this newsletter useful.
Until next week
Rob