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Critical Care Reviews Newsletter
Newsletter 566 | October 16th, 2022
Please support our work to share science
CCR23 Registration Opens Monday, October 17th
Welcome to the 566th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials comparing paroxetine or quetiapine combined with oxycodone vs oxycodone alone on ventilation during hypercapnia & levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus; systematic reviews and meta analyses on prognostic factors associated with mortality among patients receiving vv-ECMO for COVID-19 & the association of neurocritical care services with mortality and functional outcomes for adults with brain injury; and observational studies on transfusion practice in patients receiving vv-ECMO & emergency TAVI for acute heart failure due to severe aortic stenosis in critically ill patients.
There are also guidelines on point-of-care ultrasound & processed EEG-based monitoring to guide sedation; narrative reviews on biomarkers in sepsis & acute encephalopathy in children; editorials on personalized medicine in COVID-19 & existing challenges in paediatric critical care; and commentaries on a renaissance of glucocorticoids in critical care in the era of COVID-19 & lung-protective sedation.
If you only have time to read one review article this week, try this one on mechanical circulatory support devices and treatment strategies for right heart failure.
CCR23 - June 14th to 16th
Registration for the Critical Care Reviews Meeting 2023 opens on Monday October 17th at 7pm UTC+1. If you are interested in the latest major trials in critical care, this is the meeting for you. CCR22 attracted in-person delegates from 26 countries, so if you want to attend this small niche event, it's best to book early. For those who can't attend in-person, we will livestream the entire conference for free, ensuring equity of access to the latest scientific advances in our field. However, nothing quite beats the anticipation of being in Titanic Belfast to hear the results of the latest landmark trials presented for the first time and discussed in depth by an expert panel and audience.
PILOT Trial Results Livestream - Monday, October 24th
We're delighted to announce our next livestream will be the results presentation of the PILOT trial, a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation. As usual, this will be a full, free livestream including results, independent editorial, viewers questions and expert panel discussion. It is scheduled to start at 20:00 UTC+1. More details will follow over the coming days.
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Research
Randomised Controlled Trials
- Florian. Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia. A Randomized Clinical Trial. JAMA 2022;328(14):1405-1414
- Nakamura. Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial. J Neurol Neurosurg Psychiatry 2022;epublished October 7th
- Perera. Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction. N Engl J Med 2022;387:1351-1360
- Tao. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion. N Engl J Med 2022;387:1361-1372
- Jovin. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. N Engl J Med 2022;387:1373-1384
- Hashmi. Decompressive Craniectomy for the Treatment of Severe Diffuse Traumatic Brain Injury: A Randomized Controlled Trial. Asian Journal of Neurosurgery 2022;epublished October 8th
- Bharathi. Randomized control study of nebulized colistin as an adjunctive therapy in ventilator-associated pneumonia in pediatric postoperative cardiac surgical population. Ann Card Anaesth 2022;25:435-40
- Cuzco. Impact of a Nurse-Driven Patient Empowerment Intervention on the Reduction in Patients’ Anxiety and Depression During ICU Discharge: A Randomized Clinical Trial. Crit Care Med 2022;epublished September 30th
- Patel. A Randomised trial of anti-GM-CSF Otilimab in severe COVID-19 pneumonia (OSCAR). Eur Respir J 2022;epublished October 13th
- Carvelli. Avdoralimab (Anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FOR COVID Elimination [FORCE]). Crit Care Med 2022;epublished October 11th
- Rein. Randomized Phase 3 Trial of Ruxolitinib for COVID-19-Associated Acute Respiratory Distress Syndrome. Crit Care Med 2022;epublished October 13th
Systematic Review & Meta Analyses
- Tran. Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Lancet Respir Med 2022;epublished October 10th
- Nam. Resuscitation Fluids for Patients at High Risk of Multiple Organ Dysfunction Syndromes: A Systematic Review and Meta-analysis. Korean J Clin Pharm 2022;32(3):251-259
- Briard. Infratentorial Brain Injury Among Patients Suspected of Death by Neurologic Criteria: A Systematic Review and Meta-analysis. Neurology 2022;epublished October 11th
- Pham. Association of Neurocritical Care Services With Mortality and Functional Outcomes for Adults With Brain Injury: A Systematic Review and Meta-analysis. JAMA Neurol 2022;79(10):1049-1058
- Garside. Increased long-term mortality following new-onset atrial fibrillation in the intensive care unit: A systematic review and meta-analysis. J Crit Care 2022;72:154161
- Duval. Effect of Intermittent Pneumatic Compression in Addition to Pharmacologic Prophylaxis for Thromboprophylaxis in Hospitalized Adult Patients: A Systematic Review and Meta-Analysis. Crit Care Explor 2022;4(10):e0769
- Zhao. Efficacy and safety of methylene blue in patients with vasodilatory shock: A systematic review and meta-analysis. Front Med 2022;9:950596
- Savoie-White. The use of early neuromuscular blockage in acute respiratory distress syndrome: A systematic review and meta-analyses of randomized clinical trials. Heart & Lung 2022;epublished October 12th
Observational Studies
- Martucci. Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study. Lancet Respir Med 2022;epublished October 11th
- Grapsa. Association Between Vaccination Status and Mortality Among Intubated Patients With COVID-19-Related Acute Respiratory Distress Syndrome. JAMA Netw Open 2022;5(10):e2235219
- Gathier. Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Crit Care 2022;72:154124
- Duclos. Nurse-to-Nurse Familiarity and Mortality in the Critically Ill. A Multicenter Observational Study. Am J Respir Crit Care Med 2022;epublished October 11th
- Shekar. Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med 2022;epublished October 10th
- Ohbe. Low-Flow Duration and Outcomes of Extracorporeal Cardiopulmonary Resuscitation in Adults With In-Hospital Cardiac Arrest: A Nationwide Inpatient Database Study. Crit Care Med 2022;epublished October 3rd
- Gouel-Cheron. Epidemiology of ICU-Onset Bloodstream Infection: Prevalence, Pathogens, and Risk Factors Among 150,948 ICU Patients at 85 U.S. Hospitals. Crit Care Med 2022;epublished October 3rd
- Havranek. Initial rhythm and survival in refractory out-of-hospital cardiac arrest. Post-hoc analysis of the Prague OHCA randomized trial. Resuscitation 2022;epublished October 12th
- Shekar. Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med 2022;epublished October 10th
- Shehabi. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III). Am J Respir Crit Care Med 2022;epublished October 10th
- Carlton. New and Progressive Medical Conditions After Pediatric Sepsis Hospitalization Requiring Critical Care. JAMA Pediatr 2022;epublished October 10th
- Steffen. Emergency TAVI for acute heart failure due to severe aortic stenosis in critically ill patients with or without cardiogenic shock. Eur Heart J Acute Cardiovasc Care 2022;epublished October 10th
- Kwon. Early Outcomes of Heart Transplantation Using Donation After Circulatory Death Donors in the United States. Circulation 2022;epublished October 10th
- de Prost. Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19. Nat Commun 2022;13(1):6025
- Hu. Health-related quality of life after restrictive versus liberal RBC transfusion for cardiac surgery: Sub-study from a randomized clinical trial. Transfusion 2022;62(10):1973-1983
- Martucci. Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study. Lancet Respir Med 2022;epublished October 11th
- Grapsa. Association Between Vaccination Status and Mortality Among Intubated Patients With COVID-19-Related Acute Respiratory Distress Syndrome. JAMA Netw Open 2022;5(10):e2235219
- Gathier. Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Crit Care 2022;72:154124
Protocols
Guidelines
- EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) LONG VERSION. Ultraschall Med 2022;epublished October 13th (short version)
- Rasulo. Processed Electroencephalogram-Based Monitoring to Guide Sedation in Critically Ill Adult Patients: Recommendations from an International Expert Panel-Based Consensus. Neurocrit Care 2022;epublished July 27th
- Follow-up strategies for patients with splenic trauma managed non-operatively: the 2022 World Society of Emergency Surgery consensus document. World J Emerg Surg 2022;17(1):52
Reviews
Clinical
COVID-19
Neurological
- Agrawal. Cisternostomy in Traumatic Brain Injury for a Novel Approach to Treatment: Review of Current Status. Indian J Neurotrauma 2022;19(01):034-039
- Balik. Autonomic Dysreflexia following Spinal Cord Injury. Asian J Neurosurg 2022;17(02):165-172
Circulatory
- Kapur. The science of safety: complications associated with the use of mechanical circulatory support in cardiogenic shock and best practices to maximize safety. F1000Research 2020;9(Faculty Rev):794
- Kuroda. Mechanical circulatory support devices and treatment strategies for right heart failure. Front Cardiovasc Med 2022;9:951234
- Muscogiuri. Multimodality Imaging of Sudden Cardiac Death and Acute Complications in Acute Coronary Syndrome. J Clin Med 2022;11(19):5663
- Hennessey. Acute Ischaemic Mitral Valve Regurgitation. J Clin Med 2022;11(19):5526
- Toriello. Cardiac Implantable Electronic Devices Infection Assessment, Diagnosis and Management: A Review of the Literature. J Clin Med 2022;11(19):5898
Respiratory
- Chopard. An Update on the Management of Acute High-Risk Pulmonary Embolism. J Clin Med 2022;11(19):4807
- Thomas. Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients: From Pathophysiology to Clinical Practice. JACC Adv 2022;1(3):100065
- Almanza-Hurtado. Hypercapnia from Physiology to Practice. Int J Clin Pract 2022;2635616
- Cesarano. Helmet noninvasive support for acute hypoxemic respiratory failure: rationale, mechanism of action and bedside application. Ann Intensive Care 2022;12(1):94
Gastrointestinal
- Sartelli. A Proposal for a Classification Guiding the Selection of Appropriate Antibiotic Therapy for Intra-Abdominal Infections. Antibiotics 2022;11:1394
- Walkowska. The Pancreas and Known Factors of Acute Pancreatitis. J Clin Med 2022;11(19):5565
Renal
- Prastaro. Cardiorenal syndrome: Pathophysiology as a key to the therapeutic approach in an under-diagnosed disease. J Clin Ultrasound 2022 Oct;50(8):1110-1124
- Junho. Cardiorenal syndrome: long road between kidney and heart. Heart Fail Rev 2022 Nov;27(6):2137-2153
- Kim. Pathophysiology of Drug-Induced Hyponatremia. J Clin Med 2022;11(19):5810
- Chaudhari. Contrast-Induced Acute Kidney Injury: Evidence in Support of Its Existence and a Review of Its Pathogenesis and Management. Int J Nephrol Renovasc Dis 2022;15:253—266
Sepsis
- Liu. Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Military Med Res 2022;9;56
- von Groote. Biomarkers for the Prediction and Judgement of Sepsis and Sepsis Complications: A Step towards precision medicine? J Clin Med 2022;11(19):5782
- Huang. Review and Updates on the Diagnosis of Tuberculosis. J Clin Med 2022;11(19):5826
- Paquet. Fever in the Returning Traveler. Dtsch Arztebl Int 2022;119:400-7
Paediatrics
- Antalová. Ventilator-Associated Pneumonia Prevention in Pediatric Patients: Narrative Review. Children 2022;9:1540
- Imataka. A Comprehensive Review of Pediatric Acute Encephalopathy. J Clin Med 2022;11(19):59211
- Ramien. Pediatric SJS-TEN: Where are we now? F1000Research 2020;9(Faculty Rev):982
Miscellaneous
Non-Clinical
Editorials
Commentaries
- Vincent. Ten areas for ICU clinicians to be aware of to help retain nurses in the ICU. Crit Care 2022;26(1):310
- Kassis. Lung-protective sedation: moving toward a new paradigm of precision sedation. Intensive Care Med 2022;epublished October 14th
- Shelton . Towards zero carbon healthcare: anaesthesia. BMJ 2022;379:e069030
- Winkler. Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions. Crit Care 2022;26:308
- Zochios. Acute right ventricular injury phenotyping in ARDS. Intensive Care Med 2022;epublished October 11th
- Hwang. New Federal Incentives for Diversity in Clinical Trials. N Engl J Med 2022;387:1347-1349
- Rosen. Diversity in Clinical Trials — Next Steps. N Engl J Med 2022;387:e34
Correspondence
- Cove. PEEP, p-values, and pulmonary mechanics; don’t throw the baby out with the bathwater. Crit Care 2022;26:309
- Chemaitelly. Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2. N Engl J Med 2022;epublished October 12th
- Herrera-Comoglio. Vaccine-Induced Immune Thrombocytopenia and Thrombosis after the Sputnik V Vaccine. N Engl J Med 2022;387:1431-1432
- Agrawal . OUR Score or GCS in Neurocritical Care: Modification or Adaptation. Indian J Neurotrauma 2022;19(01):052-053
Case Reports
- Keller. Perforation of the Common Carotid Artery by Crossbow Arrow Without Bleeding. Dtsch Arztebl Int 2022;119:435
- Zensen. Liver Laceration Secondary to Resuscitation. Dtsch Arztebl Int 2022;119:417
- Videla. Brain death due to neuroaspergillosis in a patient with COVID-19. Revista Española de Anestesiología y Reanimación 2022;epublished September 30th
I hope you find this newsletter useful.
Until next week
Rob