![](/templates/yootheme/cache/07/CCR_Logo-07d0c919.png)
Critical Care Reviews Newsletter
Newsletter 540 | April 17th 2022
Register for the free weekly newsletter
Critical Care Reviews Meeting 2022
Welcome to the 540th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on add-on prostaglandin E1 in vv-ECMO & closed-loop oxygen control in patients with acute hypoxemic respiratory failure receiving high flow nasal oxygen; systematic reviews and meta analyses on videolaryngoscopy versus direct laryngoscopy & intraoperative PEEP and postoperative pulmonary complications; and observational studies on dyspnea in critically ill patients receiving invasive ventilation & diarrhea during critical illness.
There are also narrative reviews on cerebral hemorrhage & neurally adjusted ventilatory assist; an editorial on fast-track extubation after cardiac surgery; and commentaries on drugs for advanced life support & tranexamic acid for trauma in the USA; as well as correspondence on COVID-19 associated pulmonary aspergillosis & challenges in sample size determination for sepsis trials.
If you only have time to read one review article this week, try this one on primary palliative care recommendations for critical care clinicians.
Critical Care Reviews Meeting 2022
If you are interested in critical care trials and the scientific evidence which underpins our practice, the Critical Care Reviews Meeting is the event for you. With 6 major trial results, reviews of 8 of the best trials of the past year, three panel discussions and the annual honorary John Hinds Lecture, our scientific programme is second to none. With a run and either pilates or yoga classes on Thursday and Friday mornings, and live music every night, our social programme isn't bad either.
For those who have registered for CCR22, accommodation is anticipated to be limited in Belfast in mid-June as the city will be very busy. if you haven't yet booked your hotel, please do so. Our delegate rates are available on the meeting webpage. Similarly, the social events are also filling up, so please book these soon if you plan to attend them. They come with live music, food and drink. We have limited space left in our free, on-site, professional creche too!
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
If you are attending the Notfallmedizin 2022 Congress in Graz this week, hopefully, I might see you there. I'll be discussing landmark trials with Prof Jean-Louis Vincent. It should be fun!
Research
Randomised Controlled Trials
- Frame. Defibrotide therapy for SARS-CoV2 Acute Respiratory Distress Syndrome (ARDS). Chest 2022;S0012-3692(22)00593-1
- Roca. Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study). Crit Care 2022;26:108
- Xia. High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial. Crit Care 2022;26:109
- Quin. Ten-Year Outcomes of Off-Pump vs On-Pump Coronary Artery Bypass Grafting in the Department of Veterans Affairs. JAMA Surg 2022;157(4):303-310
- Buchtele. Add-on Prostaglandin E1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-blind, Placebo-controlled Pilot Trial. Am J Respir Crit Care Med 2022;epublished April 15th
Systematic Review & Meta Analyses
- Hansel. Videolaryngoscopy versus direct laryngoscopy for adults undergoing tracheal intubation. Cochrane Database of Systematic Reviews 2022;4:CD011136
- Beran. Balanced Crystalloids versus Normal Saline in Adults with Sepsis: A Comprehensive Systematic Review and Meta-Analysis. J Clin Med 2022;11(7):1971
- Dayyani. Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials. Stroke 2022;epublished March 31st
- Campos. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials. Br J Anaesth 2022;epublished April 15th
Observational Studies
- Rozeboom. Development and Validation of a Multivariable Prediction Model for Postoperative Intensive Care Unit Stay in a Broad Surgical Population. JAMA Surg 2022;157(4):344-352
- Rangel. Daily Load Leveling in Surgical Critical Care—The Tip of the Utilization Iceberg. JAMA Surg 2022;157(4):353
- Zdolsek. Plasma disappearance rate of albumin when infused as a 20% solution. Crit Care 2022;26:104
- Demoule. Prevalence, Intensity, and Clinical Impact of Dyspnea in Critically Ill Patients Receiving Invasive Ventilation. Am J Respir Crit Care Med 2022;205(8):917–926
- Moazed. Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Am J Respir Crit Care Med 2022;205(8):927–935
- Dionne. Diarrhea during critical illness: a multicenter cohort study. Intensive Care Med 2022;epublished April 11th
- Pedersen. Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery: Results From an International Observational Study in Relation to Recent Controlled Trials. Anesth Analg 2022;epublished April 13th
- Nesseler. Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study. Anesthesiology 2022;136:732–748
- Rasulo. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study. Crit Care 2022;26:110
Protocols
Reviews
Clinical
COVID-19
- Rovina. Fungal Infections in Critically Ill COVID-19 Patients: Inevitabile Malum. J. Clin. Med. 2022;11(7):2017
- Niazi. A Review of Extracorporeal Blood Purification Techniques for the Treatment of Critically Ill Coronavirus Disease 2019 Patients. ASAIO J 2022;epublished April 12th
Neurological
- Magid-Bernstein. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circ Res 2022;130(8):1204-1229
- Popiela. The Assessment of Endovascular Therapies in Ischemic Stroke: Management, Problems and Future Approaches. J. Clin. Med. 2022;11(7):1864
- Huynh. Tuberculous meningitis: progress and remaining questions. Lancet Neurology 2022;21(5):450-464
Circulatory
- Rhodes. Radiology of Intra-Aortic Balloon Pump Catheters. Radiology: Cardiothoracic Imaging 2022;4(2):e210120
- Weigl. Methods of assessing fluid responsiveness in septic shock patients: a narrative review. Anaesthesiol Intensive Ther 2022; 54(2):1–9
- Suzuki. Form follows function: The endothelial glycocalyx. Transl Res 2022;epublished April 11th
Respiratory
- Umbrello. Neurally Adjusted Ventilatory Assist in Acute Respiratory Failure—A Narrative Review. J. Clin. Med. 2022;11(7):1863
- Corradi. Ten conditions where lung ultrasonography may fail: limits, pitfalls and lessons learned from a computer-aided algorithmic approach. Minerva Anestesiologica 2022;88(4):308-13
Nutrition
Hepatobiliary
Perioperative
Miscellaneous
Non-Clinical
Commentaries
- Andersen. Drugs for advanced life support. Intensive Care Med 2022;epublished April 11th
- De Paulis. Anticoagulation Management in High Bleeding-Risk ECMO in Adults. Front Cardiovasc Med 2022;9:884063
- Kocher. Aligning Incentives for Improving Diagnostic Excellence. JAMA 2022;epublished April 11th
- James. Preparing Clinicians for a Clinical World Influenced by Artificial Intelligence. JAMA 2022;327(14):1333-1334
- Roberts. Tranexamic acid for trauma in the USA: is prejudice a barrier to saving lives? Lancet 2022;epublished April 13th
- Kheterpal. Digitising the prediction and management of sepsis. Lancet 2022;399(10334):1459
Correspondence
- Venturini. COVID-19 associated pulmonary aspergillosis. A real problem? Minerva Anestesiologica 2022;88(4):314-5
- Ascani. Submental intubation in major maxillofacial trauma. Minerva Anestesiologica 2022;88(4):319-20
- Evrard. Severe Acute Cor Pulmonale in Patients with COVID-19 Acute Respiratory Distress Syndrome: Caution with Left Turn. Am J Respir Crit Care Med 2022;205(8):961–964
- Spoelder. Time course of physiological variables during inter-hospital helicopter transport of ventilated COVID-19 patients. Intensive Care Med 2022;epublished April 11th
- Tran. Characterizing systematic challenges in sample size determination for sepsis trials. Intensive Care Med 2022;epublished April 12th
- Wei. Supraglottic jet oxygenation and ventilation (SJOV) for resuscitation of injured soldiers and people in war field. Military Med Res 2022;9:17
- Kopanczyk. Persistent Hypoxemia in COVID-19 Patients on ECMO: Keep Your Eyes on the Prize. J Cardiothorac Vasc Anesth 2022;epublished April 14th