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Critical Care Reviews Newsletter
Newsletter 524 | December 27th 2021
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As this is the last newsletter of 2021, it's a timely opportunity to summarise our activity over the past year. The last 12 months have been our busiest yet. We have expanded to seven different resources in the Critical Care Reviews platform - the annual meeting, livestreams, podcast, blog, annual book, newsletter and website. In addition, we have partnered with My Intensive Care, a med tech company offering a digital management solution for your ICU.
Critical Care Reviews is not-for-profit and works to promote open access to scientific advancement for the benefit of all. Everything we produce is freely accessible to everyone, everywhere. No content is paywalled, ever. If you would like to support our endeavors in sharing the latest science in critical care, please consider supporting us.
If you've missed any of our content for the year, here's a summary:
- Annual Meeting - eCCR21 - 5 major trial results, 14 major trial reviews, 3 talks on methods, interpretation and publishing, and our honorary John Hinds Lecture
- Livestreams - REMAP-CAP IL-6 antagonists | TTM2 | BASICS | RECOVERY-RS | COVID-19 Anticoagulation | VAM-IHCA | COVID-Steroid 2 | COCA | BOUGIE
- Podcasts - REMAP-CAP series (8 episodes) | INTUBE study | COAST trial | SYNAPSE-ICU study | IL-6 Antagonists Meta Analysis | TTM2 Follow-Up | BASICS Follow-Up | VAM-IHCA Follow-Up
- Blog - REST trial
- Newsletters - 52 editions
- Website - Rebuilt
PLUS Trial Results Livestream
We start 2022 in the same fashion as we finish 2021, with another major trial result livestream. On Tuesday January 18th (19th on the other side of the International Date Line), Simon Finfer will present the results of the PLUS trial, comparing 0.9% saline with plasma-lyte 148 in 5000 critically ill patients. In addition, Naomi Hammond will present a systematic review and meta analysis comparing 0.9% saline with balanced crystalloid solutions.
Research
Randomised Controlled Trials
- Li. Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery. The RAGA Randomized Trial. JAMA 2021;epublished December 20th
- Osman. Helmet continuous positive airway pressure vs. high flow nasal cannula oxygen in acute cardiogenic pulmonary oedema: a randomized controlled trial. Eur Heart J Acute Cardiovasc Care 2021;10(10):1103-1111
- Finn. Prehospital continuous positive airway pressure (CPAP) for acute respiratory distress: a randomised controlled trial. Emergency Medicine Journal 2022;39:37-44
- Cid-Serra. Effect of a Multiorgan Focused Clinical Ultrasonography on Length of Stay in Patients Admitted With a Cardiopulmonary Diagnosis: A Randomized Clinical Trial. JAMA Netw Open 2021;4(12):e2138228
- Wang. Glutamine relieves the hypermetabolic response and reduces organ damage in severe burn patients: A multicenter, randomized controlled clinical trial. Burns 2021;epublished December 22nd
- Deeken. Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery. A Stepped-Wedge Cluster Randomized Clinical Trial. JAMA Surg 2021;epublished December 15th
- Bernal. Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients. N Engl J Med 2021;epublished December 16th
- Gottlieb. Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients. N Engl J Med 2021;epublished December 22nd
Systematic Review & Meta Analyses
- Elbadawi. Targeted Hypothermia Versus Targeted Normothermia In Survivors of Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Trials. Am J Med 2021;epublished December 24th
- Foran. Timing of tracheostomy in acute traumatic spinal cord injury: A systematic review and meta-analysis. J Trauma Acute Care Surg 2022;92(1):223-231
- Wang. Non-Invasive Ventilation Strategies in Children With Acute Lower Respiratory Infection: A Systematic Review and Bayesian Network Meta-Analysis. Front Pediatr 2021;9:749975
- Craxford. Surgical management of rib fractures after blunt trauma: a systematic review and meta-analysis of randomised controlled trials. Ann R Coll Surg Engl 2021;epublished December 20th
- Su. Non-Invasive Ventilation Strategies in Children With Acute Lower Respiratory Infection: A Systematic Review and Bayesian Network Meta-Analysis. Front Pediatr 2021;9:749975
- Carson. Transfusion thresholds for guiding red blood cell transfusion. Cochrane Database Syst Rev 2021 Dec 12;12:CD002042
- Na. Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis. J Intensive Care 2021;9:75
Observational Studies
- Luyt. Efficacy of Acyclovir to Suppress Herpes Simplex Virus Oropharyngeal Reactivation in Patients Who Are Mechanically VentilatedAn Ancillary Study of the Preemptive Treatment for Herpesviridae (PTH) Trial. JAMA Netw Open 2021;4(12):e2139825
- Prinzi. Association of Endotracheal Aspirate Culture Variability and Antibiotic Use in Mechanically Ventilated Pediatric Patients. JAMA Netw Open 2021;4(12):e2140378
Guidelines
- German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients. Respiration 2021;epublished December 21st
- Thomas. Physiotherapy management for COVID-19 in the acute hospital setting and beyond: an update to clinical practice recommendations. J Physiotherapy 2021;epublished December 23rd
- Soriano. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis 2021;epublished December 21st
- de Moya. Evaluation and management of traumatic pneumothorax: A Western Trauma Association critical decisions algorithm. J Trauma Acute Care Surg 2022;92(1):103-107
- Lindbeck. Evidence-Based Guidelines for Prehospital Pain Management: Recommendations. Prehospital Emergency Care 2021;epublished December 20th
- Powell. Evidence-based Guidelines for Prehospital Pain Management: Literature and Methods. Prehospital Emergency Care 2021;epublished December 20th
Reviews
Clinical
COVID-19
- Peeling. Diagnostics for COVID-19: moving from pandemic response to control. Lancet 2021;epublished December 20th
- Maggi. Lung Ultrasound: A Diagnostic Leading Tool for SARS-CoV-2 Pneumonia: A Narrative Review. Diagnostics 2021;11(12):2381
- Bonnesen. Management of COVID-19-Associated Acute Respiratory Failure with Alternatives to Invasive Mechanical Ventilation: High-Flow Oxygen, Continuous Positive Airway Pressure, and Noninvasive Ventilation. Diagnostics 2021;11(12):2259
- Zhou. A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoV. Front Med 2021;8:628370
- Wu. Diagnostic techniques for COVID-19: A mini-review. J Virol Methods 2021 Dec 18;114437
- Ahmed. Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review. Ann Med Surg 2022;73:102988
Neurological
Circulatory
Respiratory
- Singer. Dangers of hyperoxia. Crit Care 2021;25:440
- Arrivé. Early Identification and Diagnostic Approach in Acute Respiratory Distress Syndrome (ARDS). Diagnostics 2021;11(12):2307
Gastrointestinal
Renal
Sepsis
Trauma
- Wang. Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature. Front Surg 2021;8:698736
- Picetti. Perioperative Management of Polytrauma Patients with Severe Traumatic Brain Injury Undergoing Emergency Extracranial Surgery: A Narrative Review. J Clin Med 2022;11(1):18
- Carr. A contemporary algorithm to manage acute rib fractures in the intensive care unit. J Cardiothorac Trauma 2021;6:4-14
Paediatrics
- Ruoss. Lung Ultrasound in the Neonatal Intensive Care Unit: Does It Impact Clinical Care? Children 2021;8(12):1098
- Kadafi. Clinical review of High Flow Nasal Cannula and Continuous Positive Airway Pressure in pediatric acute respiratory distress. Ann Med Surg 2022;73:103180
Perioperative
- Tschan. Coagulation and Aging: Implications for the Anesthesiologist. Curr Anesthesiol Rep 2021;11:387–395
- Halle-Smith. Improving Outcomes for Elderly Patients Following Emergency Surgery: a Cutting-edge Review. Curr Anesthesiol Rep 2021;11:396–404
- Niimi. Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know. J Cardiothor Vasc Anesth 2022;36(1):286-302
- McNamara. Perioperative Management of the Fontan Patient for Cardiac and Noncardiac Surgery. J Cardiothor Vasc Anesth 2022;36(1):275-285
Miscellaneous
Editorials
Commentaries
- Johnstone. Practicing With Memories. JAMA 2021;326(23):2369
- McIntyre. COVID-19 vaccine strategies must focus on severe disease and global equity. Lancet 2021;epublished December 16th
- Fang. Omicron: A Drug Developer's Perspective. Emerg Microbes Infect 2021;epublished December 24th
- del Rio. Winter of Omicron—The Evolving COVID-19 Pandemic. JAMA 2021;epublished December 22nd
- Yamada. Blood purification could tackle COVID-19?. J Intensive Care 2021;9:74
- Goossens. The European clinical research response to optimise treatment of patients with COVID-19: lessons learned, future perspective, and recommendations. Lancet Infect Dis 2021;epublished December 21st
Correspondence
Case Reports
- Gomes de Farias. COVID-19 pneumonia and target sign. Einstein 2021;19:eAI6564
- Wang. Myocardial Bridge or Something Else? J Cardiothor Vasc Anesth 2022;36(1):332-337
- Biswas. COVID-19 Induced Miller Fisher Syndrome Presenting With Autonomic Dysfunction: A Unique Case Report and Review of Literature. Neurohospitalist 2022;12(1):111-116