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Critical Care Reviews Newsletter
Newsletter 495 | June 7th 2021
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TTM2 Trial Results Livestream June 16th
Welcome to the 495th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. I'm out of time this week, so I'll leave you to browse the articles below. If you are in the UK, a quick reminder that the UK Critical Care Research Forum is on virtually this Thursday and Friday.
Critical Care Reviews Trials Results Meeting - The TTM2 Trial
Critical Care Reviews is delighted to announce the hosting of the much anticipated results of the TTM2 trial, on Wednesday night, June 16th, 20:15 to 22:00 UTC. As a follow up to the landmark TTM trial, comparing targeted temperature management of 33°C with 36°C in unconscious survivors of an out-of-hospital cardiac arrest, TTM2 compares a target temperature of 33°C after cardiac arrest with normothermia and early treatment of fever (≥37.8°C). The trial background and results will be delivered by three members of the TTM2 trial team (Niklas Nielsen, Josef Dankiewicz & Gisela Lilja); the editorial will be given by Prof Stephen Bernard, the chief investigator of the original Australian hypothermia trial from 2002; and the panel discussion will include Prof Jerry Nolan (Editor-in-Chief Resuscitation journal and European Resuscitation Council member; Bath, England), Prof Kathy Rowan (Director of ICNARC, London, England), and Prof Catherine Hough (Intensivist & Researcher, Oregon, USA). As usual, this will be a free livestream on the CCR wesite, accessible to all without the need for registration. Please do share this information with your colleagues to maximise the dissemination of the results of this important trial.
Research
Randomised Controlled Trials
- Cohen. BLAZE-2 Investigators. Effect of bamlanivimab vs placebo on incidence of COVID-19 among residents and staff of skilled nursing and assisted living facilities: a randomized clinical trial. JAMA 2021;epublished June 3rd
- Lopes. Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021;epublished June 4th
- Robin. Information Pamphlet Given to Relatives During the End-of-Life Decision in the ICU. An Assessor-Blinded, Randomized Controlled Trial. Chest 2021;159(6):2301-2308
- Vanderbeke. Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial. Intensive Care Med 2021;epublished May 29th
- Jayakumar. Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection—A Multicenter Feasibility Randomized Controlled Trial. J Intensive Care Med 2021;epublished May 5th
Systematic Review & Meta Analyses
- Vaschetto. Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials. Crit Care 2021;25:189
- Azadian. Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials. J Intensive Care Med 2021;epublished June 2nd
- Elsayed. Variation in outcome of invasive mechanical ventilation between different countries for patients with severe COVID-19: A systematic review and meta-analysis. PLoS One 2021;16(6):e0252760
- Lewis. Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation. A Systematic Review and Meta-analysis of Randomized Trials. 2274-2288
- Vallabhajosyula. Impact of Right Ventricular Dysfunction on Short-term and Long-term Mortality in Sepsis. A Meta-analysis of 1,373 Patients. Chest 2021;159(6):2254-2263
- Hasegawa. Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation. A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chest 2021;159(6):2289-2300
- van de Sande. Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit. Intensive Care Med 2021;epublished June 5th
- Sud. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis. Am J Respir Crit Care Med 2021;203(11):1366–1377
- Moran. Multivariate Meta-Analysis of the Mortality Effect of Prone Positioning in the Acute Respiratory Distress Syndrome. J Intensive Care Med 2021;epublished May 4th
Observational Studies
- Goligher. Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance. Am J Respir Crit Care Med 2021;203(11):1378–1385
- Spinelli. Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS. Crit Care 2021;25:192
- Shi. COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study. Crit Care 2021;25:186
- Wang. Phenotypes and Subphenotypes of Patients With COVID-19. A Latent Class Modeling Analysis. Chest 2021;159(6):2191-2204
- Shashikumar. Development and Prospective Validation of a Deep Learning Algorithm for Predicting Need for Mechanical Ventilation. Chest 2021;159(6):2264-2273
- Nseir. Relationship Between Obesity and Ventilator-Associated Pneumonia. A Post Hoc Analysis of the NUTRIREA2 Trial. Chest 2021;159(6):2309-2317
- Mumoli. Bedside Abdominal Ultrasound in Evaluating Nasogastric Tube Placement. A Multicenter, Prospective, Cohort Study. Chest 2021;159(6):2366-2372
- Tacquard. Impact of High-Dose Prophylactic Anticoagulation in Critically Ill Patients With COVID-19 Pneumonia. Chest 2021;159(6):2417-2427
- Qadir. Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States. Chest 2021;epublished June 2nd
- Carenzo. Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19. Ann Intensive Care 2021;11:91
- Laurent. Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic. Ann Intensive Care 2021;11:90
Guidelines
- Joint EAPCI/ACVC expert consensus document on percutaneous ventricular assist devices. Eur Heart J Acute Cardiovasc Care 2021;epublished May 31st
- Srivastava. Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom. Br J Anaesth 2021;126(6):1208-1216
Reviews
Clinical
COVID-19
- O’Donnell. Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis. Intensive Care Med 2021;epublished May 30th
- Mucha. Update to coagulopathy in COVID-19: Manifestations and management. Cleve Clin J Med 2021;epublished June 2nd
- Battaglini. Non-invasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. Br J Anaesth 2021;epublished June 3rd
Neurological
Circulatory
- Rroku. Update on myocarditis – what we know so far and where we may be heading. Eur Heart J Acute Cardiovasc Care 2021;10(4):455–467
- Howard. Dual antiplatelet therapy after percutaneous coronary intervention: Personalize the duration. Cleve Clin J Med 2021;88(6):325-332
Respiratory
- Demiselle. Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients. Ann Intensive Care 2021;11:88
- Kreuter. The Diagnosis and Treatment of Pulmonary Fibrosis. Dtsch Arztebl Int 2021;118:152-62
Nutrition
Miscellaneous
- Thind. Point-of-care ultrasonography for the hospitalist. Cleve Clin J Med 2021;88(6):345-359
- Choi. Interpretation of volume kinetics in terms of pharmacokinetic principles. Korean J Anesthesiol 2021;74(3):204-217
Non-Clinical
Editorials
Commentaries
- Mistraletti. Why and how to open intensive care units to family visits during the pandemic. Crit Care 2021;25:191
- Cove. Optimising the timing of renal replacement therapy in acute kidney injury. Crit Care 2021;25:184
- Wood. When Vaccine Apathy, Not Hesitancy, Drives Vaccine Disinterest. JAMA 2021;epublished June 2nd
- Brown. Famous and not-so-famous physical findings in infectious endocarditis: A look back. Cleve Clin J Med 2021;88)6):316-318
- Debate: Is It Ethically Permissible to Unilaterally Withdraw Life-Sustaining Treatments During Crisis Standards of Care? Chest 2021;159(6):2165-2170
Correspondence
- Carteaux. Potential protective effects of continuous anterior chest compression in the acute respiratory distress syndrome: physiology of an illustrative case. Crit Care 2021;25:187
- Gunst. Targeted treatment of iron deficiency in prolonged critical illness: an opportunity to improve survival or not?. Crit Care 2021;25:188
- Thomson. Timing of intubation in COVID-19: Not just location, location, location?. Crit Care 2021;25:193
- Various. Vaccine Breakthrough Infections with SARS-CoV-2 Variants. N Engl J Med 2021;epublished June 2nd
- Takuva. Thromboembolic Events in the South African Ad26.COV2.S Vaccine Study. N Engl J Med 2021;epublished June 2nd
- Solomon. Changes in Patterns of Hospital Visits for Acute Myocardial Infarction or Ischemic Stroke During COVID-19 Surges. JAMA 2021;epublished June 2nd
- Wall. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. Lancet 2021;epublished June 3rd
- Mitchell. Awake Proning or Trapping. Chest 2021;159(6):2505
- Fiorentino. Insights About Prone and Lateral Positioning in Spontaneously Breathing Patients With COVID-19 Pneumonia Undergoing Noninvasive Helmet CPAP Treatment. Chest 2021;159(6):2506-2507
Case Reports
- Goddard. Pulmonary Vein Thrombosis in COVID-19. Chest 2021;159(6):e361-e364
- Avci. A 19-Year-Old Pregnant Woman With Pulmonary Hypertension With Progressive Dyspnea. Chest 2021;159(6):e371-e375
- Hawes. An 80-Year-Old Man With Persistent Enterococcus faecalis Bacteremia. Chest 2021;159(6):e377-e380
- Moguillansky. A 44-Year-Old Woman With Multiple Neoplasms and Cystic Lung Disease. Chest 2021;159(6):e381-e384
- Alzghoul. A 57-Year-Old Man With Stridor and Critical Tracheal Narrowing. Chest 2021;159(6):e385-e388
- Kinoshita. A 63-Year-Old Woman With an Acute Exacerbation of Interstitial Pneumonia. Chest 2021;159(6):e389-e394
- Chieng. A 67-Year-Old Woman With Progressive Dyspnea and Innumerous Pulmonary Nodules. Chest 2021;159(6):e395-e401
- Gheyath. A 70-Year-Old Man With Conspicuous Thigh Pain and ST-Segment Elevations. Chest 2021;159(6):e403-e407
- Subramaniam. Three Variants of an Ultrasonographic Sign. Chest 2021;159(6):e409-e411
- Weber. A 31-Year-Old Man With Respiratory Failure. Chest 2021;159(6):e413-e415
- Shamil. A 25-Year-Old Man With Dengue Fever and Hypoxemic Respiratory Failure. Chest 2021;159(6):e417-e419
- Schultz. A 69-Year-Old Man With Syncope. Chest 2021;159(6):e421-e423
- Cheung. A Woman With Neck Swelling and Cardiac Arrest. Chest 2021;159(6):e425-e427
- Vaithilingam. An Intruder in the Heart. Chest 2021;159(6):e429-e431
- Sigakis. Lung Ultrasound Scans During Whole Lung Lavage. Chest 2021;159(6):433-e436
- Cui. Spontaneous Echo Contrast Mimicking Left Ventricular Thrombus in a Patient on Extracorporeal Membrane Oxygenation Support. Chest 2021;159(6):e437-e439
- Tsolaki. A Middle-Aged Woman With Viral ARDS and Acute Establishment of Shock on Invasive Mechanical Ventilation. Chest 2021;159(6):e441-e445
- Raymond. Mycoplasma pneumoniae–Induced Rash and Mucositis. Mayo Clin Proc 2021;96(6):1520-1521
- Zackary. Evolving distal signs. Cleve Clin J Med 2021;88(6):310-312