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Critical Care Reviews Newsletter
Newsletter 536 | March 20th 2022
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Future of Funding for Clinical Trials Panel Discussion at CCR22
Welcome to the 536th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on the anti-GM-CSF monoclonal antibody gimsilumab for COVID-19 pneumonia & APRV in patients with acute respiratory failure due to COVID-19; systematic reviews and meta analyses on awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure & the role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS; and an observational study on a perioperative laboratory test-based prediction model for moderate to severe AKI after cardiac surgery.
There are also guidelines on pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit & focused assessment with sonography for trauma in children; narrative reviews on brain death & whether prehospital blood transfusion should be adopted for civilian trauma; and commentaries on collider bias & my advice to the NEXT generation; as well as correspondence on the actual benefit of early antibiotics for young patients with sepsis & vitamin C for septic shock.
If you only have time to read one review article this week, try this one on challenging management dogma where evidence is non-existent, weak or outdated.
Critical Care Reviews Meeting 2022
We announced two panel discussions this week; firstly, a discussion on "the future of funding for clinical trials" between three of the major UK trial funders (Prof Jeremy Farrar from the Wellcome Trust, Prof Lucy Chappell from NIHR, & Prof Patrick Chinnery from the MRC, chaired by Prof Danny McAuley); and secondly, an exploration of "publishing with the top tier journals", featuring Prof Darren Taichmann (Deputy Editor, NEJM), Assoc Prof Christopher Seymour (Associate Editor for Critical Care, JAMA), Dr Liz Wilcox (University of Toronto), Dr Bronwen Connolly (Queen's University Belfast) and Dr Fernando Zampieri (Albert Einstein Hospital, Sao Paulo), chaired by Prof Howard Bauchner, Editor-in-Chief JAMA, 2011 - 2021.
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
Next Livestream
Our next livestream trial results presentation will be the "Step Down" component of the FIRST ABC trial, comparing CPAP with high flow nasal oxygen in recently extubated critically ill children. This is scheduled for Thursday April 7th, at 19:30 UTC+1. The "Step Up" component, comparing CPAP with HFNO in critically ill children with an acute illness requiring non-invasive respiratory support, will be presented at CCR22 in June.
Research
Randomised Controlled Trials
- Criner. Anti-GM-CSF Monoclonal Antibody Gimsilumab for COVID-19 Pneumonia: A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Respir Crit Care Med 2022;epublished March 15th
- Ibarra-Estrada. Use of Airway Pressure Release Ventilation in Patients With Acute Respiratory Failure Due to COVID-19: Results of a Single-Center Randomized Controlled Trial. Crit Care Med. 2022;50(4):586–594
- Barrett. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest 2022;161(3):710-727
- Saxena. Comparison of Effect of Non-invasive Ventilation Delivered by Helmet vs Face Mask in Patients with COVID-19 Infection: A Randomized Control Study. Indian J Crit Care Med 2022;26(3):282-287
- Aoun. Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial. BMC Nephrol 2022;23(1):100
Systematic Review & Meta Analyses
- Li. Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis. Lancet Respir Med 2022;epublished March 16th
- Gendreau. The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis. Intensive Care Med 2022;epublished March 16th
- Naseri. Probiotics in Critically Ill Patients: An Umbrella Review. Indian J Crit Care Med 2022;26(3):339-360
- Boucher. The Cost of ARDS. A Systematic Review. Chest 2022;161(3):684-696
- Cao. Diagnostic accuracy of cardiopulmonary ultrasound for pulmonary embolism: A systematic review and meta-analysis. Echocardiography 2022;39(2):185-193
- Sardaneh. Efficacy and safety of metaraminol in critically ill patients with shock: a systematic review. J Pharm Pract Res 2022;epublished March 11th
Observational Studies
- Demirjian. Predictive Accuracy of a Perioperative Laboratory Test-Based Prediction Model for Moderate to Severe Acute Kidney Injury After Cardiac Surgery. JAMA 2022;327(10):956-964
- Clark. Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study. Lancet Neurol 2022;epublished March 16th
- Itaya. The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19. JAMA Netw Open 2022;5(3):e222973
- Rüddel. Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial. Crit Care 2022;26:51
- Takagi. Early echocardiography by treating physicians and outcome in the critically ill: An ancillary study from the prospective multicenter trial FROG-ICU. J Crit Care 2022;69:154013
Guidelines
- 2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit. Acute Crit Care 2022;37(1):1-25
- Kornblith. Development of a Consensus-Based Definition of Focused Assessment With Sonography for Trauma in Children. JAMA Netw Open 2022;5(3):e222922
Reviews
Clinical
COVID-19
- Chatterjee. An update of antispike severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies. Indian J Pharmacol 2022;54:51-7
- Paediatr. Schulzke.Update on ventilatory management of extremely preterm infants-A Neonatal Intensive Care Unit perspective. Paediatr Anaesth 2022;32(2):363-371
- Gabelloni. Extracorporeal membrane oxygenation (ECMO) in COVID-19 patients: a pocket guide for radiologists. Radiol Med 2022;epublished March 13th
Neurological
Circulatory
- Crapnell. Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review. Microchim Acta 2022;189:142
- Takaokal. Quality indicators of palliative care for cardiovascular intensive care. j intensive care 2022;10:15
Respiratory
Hepatobiliary
Sepsis
- Andersson. HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis. J Intensive Med 2022;epublished March 9th
- Wang. Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics. Front Pharmacol 2022;13:839808
- Tabah. Use of Antimicrobials for Bloodstream Infections in the Intensive Care Unit, a Clinically Oriented Review. Antibiotics 2022;11:362
Trauma
Toxicology
Paediatrics
- Trachsel. Developmental respiratory physiology. Paediatr Anaesth 2022;32(2):108-117
- Spaeth. Understanding pediatric ventilation in the operative setting. Part I: Physical principles of monitoring in the modern anesthesia workstation. Paediatr Anaesth 2022;32(2):237-246
- Spaeth. Understanding pediatric ventilation in the operative setting. Part II: Setting perioperative ventilation. Paediatr Anaesth 2022;32(2):247-254
- Karlsson. Capnodynamics—Measuring cardiac output via ventilation. Paediatr Anaesth 2022;32(2):255-261
- Rocha. Novel ventilation techniques in children. Paediatr Anaesth 2022;32(2):286-294
Miscellaneous
Non-Clinical
Commentaries
Correspondence
- Watanabe. The Actual Benefit of Early Antibiotics for Young Patients With Sepsis. Chest 2022;161(3):e195
- Lee. Vitamin C for septic shock in previous randomized trials: implications of erroneous dosing, timing, and duration. Crit Care 2022;26:61
- de Zalán. Inhaled iloprost can improve oxygenation and shunt fraction in severe COVID-19. Acute Crit Care 2022;37(1):127-130
- Nunez. It takes two to bleed: anticoagulation intensity and the host’s vascular susceptibility. Author’s reply. Intensive Care Med 2022;epublished March 14th
- Van Dijck. Ketamine for emergency endotracheal intubation: insights into post-induction hemodynamic instability. Intensive Care Med 2022;epublished March 7th
- van Genderen. Management and outcome of critically ill pregnant women with COVID-19. Intensive Care Med 2022;epublished March 14th
Case Reports
- Gilmartin. Rapid-Onset Cystic Bronchiectasis in a Mechanically Ventilated Patient with COVID-19. Am J Respir Crit Care Med 2022;205(6):721–722
- Beck. Immersion-Induced Mitral Regurgitation. A Novel Risk Factor for Swimming-Induced Pulmonary Edema. Chest 2022;161(3):e137-e143
- Loeb. Encephalopathy in a Recent Lung Transplant Recipient. Chest 2022;161(3):e149-e152
- Hoan. A 32-Year-Old Man With Dyspnea and Stridor. Chest 2022;161(3):e153-e157
- Soong. A 37-Year-Old Woman Presenting With Hemoptysis, Dyspnea and Fever. Chest 2022;161(3):e159-e162
- Tran. Hypoxemia in a Patient Receiving Venovenous Extracorporeal Membrane Oxygenation. Chest 2022;161(3):e181-e183
- Liu. Murmur in a 62-Year-Old Man After Inferior Wall Myocardial Infarction. Seeing Is Believing? Chest 2022;161(3):e185-e189
- Ko. A 57-Year-Old Woman With Fever, Urinary Frequency, and Shock. Chest 2022;161(3):e191-e193
- Perez-Gomez. The mysterious death of the beer drinking champ: potential role for hyperacute water loading and acute hyponatremia (HAWLAH). Clin Kid J 2022;sfac072
- Concha. Invasive mechanical ventilation and prolonged prone position during the COVID-19 pandemic. Medicina Intensiva 2022;46(3):161-163
- Shi. A case of unilateral pulmonary oedema associated with severe acute mitral regurgitation. Clin Med 2022;22:160-162
- Sen. Histoacryl glue embolisation to the right ventricle following treatment for gastric varices. Clin Med 2022;22:163-164
- El-Alali. Thinking Beyond Acute Kidney Injury. Case Rep Nephrol Dial 2022;12:16–21
- Urbina. COVID-19-associated Multi-Inflammatory Syndrome in Adults (MIS-A): look into the eyes!. Intensive Care Med 2022;epublished March 14th
- Alhemeiri. Euglycemic Diabetic Ketoacidosis after Discontinuing SGLT2 Inhibitor. Case Rep Endocrinol 2022;2022:4101975
- El-Alali. Thinking Beyond Acute Kidney Injury. Case Rep Nephrol Dial 2022;12:16–21