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Critical Care Reviews Newsletter
Newsletter 526 | January 10th 2022
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Registration is now open for CCR22
Welcome to the 526th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials investigating atorvastatin in critically ill patients with COVID-19 & the prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes; systematic reviews and meta analyses on balanced versus unbalanced fluids in critically ill children & prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome; and observational studies on monitoring spinal cord tissue oxygen in patients with acute, severe traumatic spinal cord injuries & brain biopsy for neurological diseases of unknown etiology in critically ill patients.
There are also guidelines on plasma and platelet transfusion practice in critically ill children & multisystem inflammatory syndrome related to COVID-19; narrative reviews on biomarkers for sepsis & when to change treatment of acute invasive aspergillosis; commentaries on the rational diagnostician and achieving diagnostic excellence & routine use of point-of-care lung ultrasound during the COVID-19 pandemic; an editorial on coming to terms with a new normal: recovery, resilience, and opportunities in a Post-Covid World; as well as correspondence on awake prone positioning on diaphragmatic function.
If you only have time to read one review article this week, try this one on resuscitation fluids as drugs: targeting the endothelial glycocalyx.
Critical Care Reviews Meeting 2022
Registration has opened for CCR22, featuring major trial result presentations, reviews of the best trials of the previous year and discussions on trial methodology, interpretation and publishing. It's on June 15th to 17th, in Titanic Belfast. As an opener, we have the results presentations of the CLASSIC trial, comparing conservative with liberal fluid therapy in septic shock; LOVIT, investigating vitamin C in sepsis; and the long term outcomes of HOT-ICU, examining liberal and conservative oxygenation targets in patients with hypoxaemic respiratory failure. We also will have the chief investigators present each of TTM2 (targeted temperature management after out-of-hospital cardiac arrest), PLUS (0.9% saline vs plama-lyte 148 for fluid resuscitation), COAST (oxygenation strategies in African children with pneumonia), VAM-IHCA (vasopressin, methylprednisolone and adrenaline for in-hospital cardiac arrest) and SUDDICU (selective decontamination of the digestive tract). The programme will continue to grow as more trials are added. As usual, we have a superb social programme to match our scientific programme, and offer our standard free on-site childcare and reduced maternity and paternity registration rates.
PLUS Trial Result Livestream
Join us next week, on Tuesday 18th 20:00 (UTC +0), for the livestream of the PLUS trial results presentation. PLUS is a large multi-centre randomised controlled trial comparing 0.9% saline with plasmalyte-148 in 5000 critically ill patients. It follows on from the BASICS trial result we had in August and further adds to the growing evidence base in the field. After Simon Finfer presents the results of the PLUS trial, Naomi Hammond will present an up-to-date systematic review and meta analysis comparing balanced fluids with 0.9% saline. We have a superb faculty organised, with Deborah Cook giving the editorial, and a panel discussion including John Kellum, Gordon Guyatt, Tomoko Fujii and Jeff Drazen. The livestream will be freely available on the Critical Care Reviews website.
Research
Randomised Controlled Trials
- INSPIRATION-S Investigators. Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial. BMJ 2022;376:e068407
- Abrard. Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial. Br J Anaesth 2022;epublished January 5th
- Damas. Prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes: a multi-center, randomized, double-blind study. Ann Intensive Care 2022;12:1
- Wacker. Evaluating Vitamin C in Septic Shock. A Randomized Controlled Trial of Vitamin C Monotherapy. Crit Care Med 2022;epublished January 5th
- Odeyemi. Early, biomarker-guided steroid dosing in COVID-19 Pneumonia: a pilot randomized controlled trial. Crit Care 2022;26:9
- Santamarina. Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial. Crit Care 2022;26:1
Systematic Review & Meta Analyses
- Holmberg. Vasopressin and Glucocorticoids for In-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis of Individual Participant Data. Resuscitation 2022;epublished January 3rd
- Henry. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatr Res 2022;epublished January 7th
- Giani. Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis. Crit Care 2002;26:8
- Lehr. Balanced Versus Unbalanced Fluid in Critically Ill Children. Systematic Review and Meta-Analysis. Ped Crit Care Med 2022;epublished January 6th
- Lilien. Association of Arterial Hyperoxia With Outcomes in Critically Ill ChildrenA Systematic Review and Meta-analysis. JAMA Netw Open 2022;5(1):e2142105
Observational Studies
- Mathon. Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield. Crit Care Med 2022;epublished January 10th
- Lakhal. Intravenous Milrinone for Cerebral Vasospasm in Subarachnoid Hemorrhage: The MILRISPASM Controlled Before–After Study. Neurocrit Care 2021;35:669–679
- Esperatti. Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study. Crit Care 2022;26(1):16
- Brown. Association between unmet medication needs after hospital discharge and readmission or death among acute respiratory failure survivors: the addressing post-intensive care syndrome (APICS-01) multicenter prospective cohort study. Crit Care 2002;26:6
- Boutin. Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission. Crit Care 2022;26:13
- Bhalla. Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study. Crit Care 2022;26:2
- Visagan. Monitoring Spinal Cord Tissue Oxygen in Patients With Acute, Severe Traumatic Spinal Cord Injuries. Crit Care Med 2022;epublished January 6th
- Rouzé. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study. Crit Care 2022;26:11
- Funk. Persistence of live virus in critically ill patients infected with SARS-COV-2: a prospective observational study. Crit Care 2022;26:10
Protocols
Guidelines
- Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Ped Crit Care Med 2022;23(1):34-51
- Tabbutt. Standardized Training for Physicians Practicing Pediatric Cardiac Critical Care. Ped Crit Care Med 2022;23(1):60-64
- Algarni. Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations. World J Pediatr 2022;epublished January 4th
- Nephrotoxins and acute kidney injury – The consensus of the Taiwan acute kidney injury Task Force. J Formos Med Assoc 2022;epublished January 5th
Reviews
Clinical
COVID-19
- Drain. Rapid Diagnostic Testing for SARS-CoV-2. N Engl J Med 2022;epublished January 7th
- Iba. Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia. Crit Care Med. 2022;50(1):e80–e86
- Pillai. Coronavirus disease 2019 and cardiovascular diseases: collateral damage? Curr Opin Anaesthesiol 2022;35(1):5–11
- Nair. Happy hypoxemia: A perplexing clinical entity in coronavirus disease 2019. J Appl Pharm Sci 2022;12(01):065–069
- Paludan. Innate immunological pathways in COVID-19 pathogenesis. Sci Immunol 2022;7(67):eabm5505
Neurological
- Lozada-Martínez. Neurogenic pulmonary edema in subarachnoid hemorrhage: relevant clinical concepts. Egypt J Neurosurg 2022;36:27
- Jha. Emerging therapeutic targets for cerebral edema. Expert Opin Ther Targets 2022;epublished January 2nd
Circulatory
- Wang. Resuscitation fluids as drugs: targeting the endothelial glycocalyx. Chin Med J 2022;epublished January 4th
- Assad. Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management. Clin Med Insights Cardiol 2022;16:11795468211065782
- Yamada. Cardiac and vascular point-of-care ultrasound: current situation, problems, and future prospects. J Med Ultrasonics 2022;epublished January 8th
Airway
Respiratory
- Hussain. Acute Respiratory Distress Syndrome and COVID-19: A Literature Review. J Inflamm Res 2021;14:7225-7242
- Suárez-Sipmann. Monitoring Expired CO 2 Kinetics to Individualize Lung-Protective Ventilation in Patients With the Acute Respiratory Distress Syndrome. Front Physiol 2021;12:785014
- Tobin. Pulse oximetry, racial bias and statistical bias. Ann Intensive Care 2022;12:2
- Jha. Perioperative Pulmonary Atelectasis: Part II. Clinical Implications. Anesthesiology 2022;136:206–236
Gastrointestinal
- Szychowiak. The role of the microbiota in the management of intensive care patients. Ann Intensive Care 2022;12:3
- Havlichek III. A Practical Guide to the Evaluation of Small Bowel Bleeding. Mayo Clin Proc 2022;97(1):146-153
Nutrition
Sepsis
- Barichello. Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review. Crit Care 2022;26:14
- Slavin. When to change treatment of acute invasive aspergillosis: an expert viewpoint. J Antimicrobial Chemotherapy 2022;77(1):16–23
- Zhou. Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury. Front Microbiol 2021;12:779620
- Terrier. Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges. PLoS Pathog 2021;17(12):e1010106
Obstetrics
Perioperative
Miscellaneous
Editorials
- Oakes. Coming to terms with a new normal: Recovery, resilience, and opportunities in a Post-Covid World. J Cardiovasc Thorac Anesth 2022;epublished January 3rd
- Hillerson. Continuity of Critical Care: Establishing a Cardiac Intensive Care Unit Recovery Clinic. JACC Case Rep 2021;3(18):1932-1935
- Morshuis. We enter the bridge and start to run out of time. J Cardiothorac Vasc Anesth 2022;epublished January 8th
- Kim. Does the volume and constitution of cardiopulmonary bypass priming fluids affect blood loss post cardiac surgery in children? J Cardiothorac Vasc Anesth 2022;epublished January 8th
Commentaries
- Antúnez-Montes. Routine use of Point-of-Care lung ultrasound during the COVID-19 pandemic. Medicina Intensiva 2021;46(1):42-45
- Azoulay. We are proud of you Jamie. Intensive Care Med 2022;epublished January 3rd
- Jacobsen. Shifting to Serious Illness Communication. JAMA 2022;epublished January 7th
- Croskerry. The Rational Diagnostician and Achieving Diagnostic Excellence. JAMA 2022;epublished January 7th
- Kelly. The philosophy of stoicism: relevance in today’s healthcare system. QJM 2021;114(11):839–840
Correspondence
- ean-Michel. Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation. Medicina Intensiva 2022;46(1):58-61
- Xu. Gut microbiota plays a pivotal role in opioid-induced adverse effects in gastrointestinal system. Crit Care 2022;26:5
- Xiao. Awake prone positioning on diaphragmatic function: Really bad or maybe good?. Crit Care 2022;25:449
- Smit. Demystifying machine learning for mortality prediction. Crit Care 2022;25:447
- Turkstra. Provider/patient conflict: is it time to reconsider the contraindication for videolaryngoscope use in a bleeding/soiled airway? Can J Anesth 2022;69:177–178
Case Reports
- Fischer. Long-Term Recovery from Disordered Consciousness Associated with COVID-19. Neurocrit Care 2021;35:916–918
- Parlow. An Unusual Case of Obstructive Shock. JACC Case Rep 2021;3(18):1913-1917
- King-Robson. Prone position plexopathy: an avoidable complication of prone positioning for COVID-19 pneumonitis? BMJ Case Rep 2022;15(1):e243798
- Mitsuyama. Refractory pneumothorax secondary to COVID-19 treated by autologous blood patch pleurodesis. QJM 2021;114(11):803–804
- Bayram. Management skin manifestation of multisystem inflammatory syndrome associated with SARS-CoV-2. Virol J 2022;19:9